Adrenergic Neurons, Geoffrey Burnstock and Marcello Costa
Автор: Jr. Ruffolo Название: The alpha-1 Adrenergic Receptors ISBN: 146128936X ISBN-13(EAN): 9781461289364 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During the past decade, great strides have been made in our un- derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor.
Автор: Lee E. Limbird Название: The alpha-2 Adrenergic Receptors ISBN: 1461289424 ISBN-13(EAN): 9781461289425 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: John P. Perkins Название: The Beta-Adrenergic Receptors ISBN: 1461267722 ISBN-13(EAN): 9781461267720 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prior to 1974, the adrenergic receptors were known only in- directly as entities that responded to drugs in a selective manner to mediate a variety of physiologically important responses. During the intervening years, our view of adrenergic receptors has changed dramatically. The availability of high affinity 125I-labeled radioligands selective for these receptors presaged an explosion of experimenta- tion utilizing direct binding assays to establish the biochemical properties of the receptor protein. In the opening chapter, Stadel and Lefkowitz describe this development and its impact on our under- standing of the molecular basis of adrenergic receptor function. The availability of well-characterized receptor ligands, coupled with the development of efficient methods for detergent solubilization, formed the basis of receptor purification using affinity chromatography. The related technique of photoaffinity labeling provided a means to estimate the molecular mass of these receptors. The availability of substantial amounts of purified 2-adrenergic receptor allowed determination of segments of its amino acid se- quence. This information led to the production of polynucleotide probes and eventually to cloning of the receptor gene and determi- nation of the complete primary sequence of the receptor protein. Caron and Lefkowitz review the investigations leading to this major development and discuss the methods involved. They analyze our current perception of the relation of receptor function to its structure and discuss the general features of the G protein-interacting receptor family, of which the -adrenergic receptors are prototypes.
Автор: Curtis A. Machida Название: Adrenergic Receptor Protocols ISBN: 1489941568 ISBN-13(EAN): 9781489941565 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Adrenergic Receptor Protocols consists of 35 chapters dealing with va- ous aspects of adrenergic receptor analyses, including the use of genetic, RNA, protein expression, transactivator, second messenger, immunocytochemical, electrophysiological, transgenic, and in situ hybridization approaches.
Описание: Gordon Fain`s Molecular and Cellular Physiology of Neurons, Second Edition is intended for anyone who seeks to understand nerve cell function: undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries.
Автор: Jeroen Pasterkamp; Marten P. Smidt; J. Peter H. Bu Название: Development and Engineering of Dopamine Neurons ISBN: 1441903216 ISBN-13(EAN): 9781441903211 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections.
Автор: Bart De Strooper Название: Macro Roles for MicroRNAs in the Life and Death of Neurons ISBN: 364226204X ISBN-13(EAN): 9783642262043 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.
Автор: Bart De Strooper Название: Macro Roles for MicroRNAs in the Life and Death of Neurons ISBN: 364204297X ISBN-13(EAN): 9783642042973 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.
