John P. Perkins The Beta-Adrenergic Receptors 9781461267720

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Автор: John P. Perkins
Название: The Beta-Adrenergic Receptors
ISBN: 9781461267720
Издательство: Springer
Классификация:

Неврология и клиническая нейрофизиология

Фармакология

Науки о жизни (медико-биологические): общие вопросы

Нейронауки

ISBN-10: 1461267722
Обложка/Формат: Paperback
Страницы: 405
Вес: 0.58 кг.
Дата издания: 03.10.2012
Серия: The Receptors
Язык: English
Размер: 234 x 156 x 22
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Prior to 1974, the adrenergic receptors were known only in- directly as entities that responded to drugs in a selective manner to mediate a variety of physiologically important responses. During the intervening years, our view of adrenergic receptors has changed dramatically. The availability of high affinity 125I-labeled radioligands selective for these receptors presaged an explosion of experimenta- tion utilizing direct binding assays to establish the biochemical properties of the receptor protein. In the opening chapter, Stadel and Lefkowitz describe this development and its impact on our under- standing of the molecular basis of adrenergic receptor function. The availability of well-characterized receptor ligands, coupled with the development of efficient methods for detergent solubilization, formed the basis of receptor purification using affinity chromatography. The related technique of photoaffinity labeling provided a means to estimate the molecular mass of these receptors. The availability of substantial amounts of purified 2-adrenergic receptor allowed determination of segments of its amino acid se- quence. This information led to the production of polynucleotide probes and eventually to cloning of the receptor gene and determi- nation of the complete primary sequence of the receptor protein. Caron and Lefkowitz review the investigations leading to this major development and discuss the methods involved. They analyze our current perception of the relation of receptor function to its structure and discuss the general features of the G protein-interacting receptor family, of which the -adrenergic receptors are prototypes.

The Beta-Adrenergic Receptors, John P. Perkins