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DNA-Protein Interactions, A. Travers


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Автор: A. Travers
Название:  DNA-Protein Interactions
ISBN: 9780412259906
Издательство: Springer
Классификация:


ISBN-10: 0412259907
Обложка/Формат: Paperback
Страницы: 192
Вес: 0.28 кг.
Дата издания: 30.04.1993
Язык: English
Размер: 234 x 156 x 10
Основная тема: Life Sciences
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: An exploration of the molecular interactions involved in the binding of proteins to DNA and the manipulation of DNA by proteins in such processes as recombination, transcription and topomerization. The structural and mechanistic bases of these phenomena in bacteria and higher organisms is stressed.


A laboratory guide for in vivo studies of DNA methylation and protein/DNA interactions

Автор: Saluz; Jost
Название: A laboratory guide for in vivo studies of DNA methylation and protein/DNA interactions
ISBN: 3764323698 ISBN-13(EAN): 9783764323691
Издательство: Springer
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Цена: 11179.00 р.
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Описание: A Safety Considerations Genomie sequencing involves a number oj hazard- ous steps, such as high eurrent, high voltage, radioaetive and highly toxie chemieals. It is, the- jore, absolutely essential that the instruetions oj equipment manu/aeturers bejollowed and that par- tieular attention is paid to the loeal and jederal safety regulations. I Introduction 13 B Introduction Hypomethylation ofDNA has been positively correlated with thc activation of many eucaryotic genes. During the transition from inactive to active genes changes in the protein/DNA interaction pattern occur. Tran- scriptional activation of eucaryotic genes is mediated by specific interac- tions oftransacting factors with their respective DNA binding sites in Lhe control regions (promoters, enhancers) ofthe genes. This process is ofLen accompanied by changes in local chromatin strucLure, witnessed by the appearance of nuclease hypersensitive sites, as weil as by changes in protein-DNA interactions and, in the case of higher eucaryotes, alterations ofthe cytosine methylation pattern. The sole available experimental tech- nique that permits the study ofthe latter phenomena at single nucleotide resolution is direct genomic sequencing/footprinting, pioneered by Church and Gilbert (1984). This method combines the chemical DNA- sequencing procedure of Maxam amI Gilbert (1980) with thc detection 01' DNA sequences by electroblotting and indirect end-Iabeling by hybridiza- tl0n. An alternative possibility is the novel procedure (Saluz and . lost, 1989), using Taq polymerase. The first steps 01' both meLhods are essen- tially the same: total genomic DNA is digested wiLh a suilable restriction enzyme and the resulting DNA fragments are chemically sequeneed.

Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

Автор: Sebastian Doniach
Название: Statistical Mechanics, Protein Structure, and Protein Substrate Interactions
ISBN: 0306447282 ISBN-13(EAN): 9780306447280
Издательство: Springer
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Цена: 34799.00 р.
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Описание: Proceedings of a NATO ARW held in Cargese, Corsica, France, June 1-5, 1993

Regulation of Plasma Low Density Lipoprotein Levels Biopharmacological Regulation of Protein Phosphorylation Calcium-Activated Neutral Protease Microbial Iron Transport Pharmacokinetic Drug Interactions

Автор: William R. Bartle; Volker Braun; John M. Dietschy;
Название: Regulation of Plasma Low Density Lipoprotein Levels Biopharmacological Regulation of Protein Phosphorylation Calcium-Activated Neutral Protease Microbial Iron Transport Pharmacokinetic Drug Interactions
ISBN: 3642729045 ISBN-13(EAN): 9783642729041
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Since it has been demonstrated that reducing the steady-state plasma LDL-cholesterol concentration produces a proportional decrease in the risk of developing atherosclerosis 2), a major effort is now underway to develop safe and effective lipid lowering agents.

Protein-Protein Interactions / Methods and Applications

Автор: Fu Haian
Название: Protein-Protein Interactions / Methods and Applications
ISBN: 1588291200 ISBN-13(EAN): 9781588291202
Издательство: Springer
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Цена: 27950.00 р.
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Описание: A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches, such as the Scansite program for computational analysis. These powerful tools are essential for deciphering how proteins interact with each other to form biological networks, as well as for unraveling protein-protein interactions in disease to find novel therapeutic targets.

Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

Автор: Sebastian Doniach
Название: Statistical Mechanics, Protein Structure, and Protein Substrate Interactions
ISBN: 1489913513 ISBN-13(EAN): 9781489913517
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Proceedings of a NATO ARW held in Cargese, Corsica, France, June 1-5, 1993

Biophysics of DNA-Protein Interactions

Автор: Mark C. Williams; L. James Maher, III
Название: Biophysics of DNA-Protein Interactions
ISBN: 1461426952 ISBN-13(EAN): 9781461426950
Издательство: Springer
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Цена: 16977.00 р.
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Описание: Focusing on the biophysics of DNA-protein interactions, this volume presents new methods and results that explore the mechanism behind prtein and DNA interaction. Recent advances in biophysics are discussed, in addition to proteins that alter DNA properties to faciliate interactions for transcription or replication.

Protein-Protein Interactions as New Drug Targets

Автор: Enno Klussmann; John Scott
Название: Protein-Protein Interactions as New Drug Targets
ISBN: 3642091946 ISBN-13(EAN): 9783642091940
Издательство: Springer
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Цена: 65305.00 р.
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Описание: This book covers therapeutically relevant protein-protein interactions, focusing on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the field are included.

New Developments in Lipid-Protein Interactions and Receptor Function

Автор: K.W.A. Wirtz; Lester Packer; J.?. Gustafsson; A.E.
Название: New Developments in Lipid-Protein Interactions and Receptor Function
ISBN: 1461362393 ISBN-13(EAN): 9781461362395
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of a NATO ASI held in Spetsai, Greece, August 16-27, 1992

Proteomics and Protein-Protein Interactions

Автор: Gabriel Waksman
Название: Proteomics and Protein-Protein Interactions
ISBN: 1489996117 ISBN-13(EAN): 9781489996114
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London WC1E 7H United Kingdom Email: g.


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