Chemosensors of Ion and Molecule Recognition, J.P. Desvergne; A.W. Czarnik
Автор: J.P. Desvergne; A.W. Czarnik Название: Chemosensors of Ion and Molecule Recognition ISBN: 9401057591 ISBN-13(EAN): 9789401057592 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop on Chemosensors of Ion and Molecule Recognition, Bonas, France, August 31-September 4, 1996
Описание: This book deals with the physico-chemical principles underlying ion- exchange sorption and chromatog~aphy.
Автор: Bensimon, David (research Director And Professor, Lps-ens, Psl, Cnrs And Department Of Chemistry And Biochemistry, Ucla, Usa) Croquette, Vincent (re Название: Single molecule studies of nucleic acids and their associated proteins ISBN: 0198530927 ISBN-13(EAN): 9780198530923 Издательство: Oxford Academ Рейтинг: Цена: 11246.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is an introduction to the novel physical tools that allow single molecule manipulation and visualisation. It describes the use of these tools to understand the elastic properties of single molecules of DNA and RNA and to study their interactions with the many proteins that process them.
Название: Small molecule drug discovery ISBN: 0128183497 ISBN-13(EAN): 9780128183496 Издательство: Elsevier Science Рейтинг: Цена: 17180.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases.
The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.
Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery
Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics
Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches
Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules
Автор: E. Katchalski-Katzir; Georges van Binst; V. Prelog Название: Design and Synthesis of Organic Molecules Based on Molecular Recognition ISBN: 3642709281 ISBN-13(EAN): 9783642709289 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: After discovery and classification of the main types of reactions, the study of the selectivity of reactions becomes of paramount importance. To analyze the structural features applied by Nature, to accomplish high molecular recog- nition, and to simulate these features by synthesis have recently become therefore favorite occupations of chemists.
Описание: Covers the scientific principles, developments and recent technological advances of stimuli responsive materials for those new to and active in the field.
Автор: G. Dan Pantos Название: Naphthalenediimide and Its Congeners: From Molecules to Materials ISBN: 1849739226 ISBN-13(EAN): 9781849739221 Издательство: Royal Society of Chemistry Рейтинг: Цена: 35693.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Essential reference material for postdoctoral researchers and postgraduate students providing background information on naphthalenediimide chemistry.
Описание: Introduction.- The Vinylogous Reactivity of Oxindoles Bearing Non-symmetric 3-Alkylidene Groups.- Targeting the Remote Control of Axial Chirality in N-(2-tert-Butylphenyl)Succinimides via a Desymmetrization Strategy.- Direct Catalytic Synthesis of C(sp2)-C(sp3) Atropisomers with Simultaneous Control of Central and Axial Chirality.
Описание: This text discusses di-p-methane rearrangements via radical-cation intermediates, the photo-Fries rearrangement in organized media and of biologically active compounds, electron transfer leading to fragmentation, dimerization, and nucleophilic capture, and the characterization and reactivity of photochemically generated phenylene bis(diradical) species. The authors reveal experimental and computational techniques for the study of phenylene-linked carbenes and nitrenes. Brimming with over 900 references, Photochemistry of Organic Molecules in Isotropic and Anisotropic Media is crucial for professionals and students in photochemistry; chemical engineering; materials and semiconductor science; and organic, inorganic, and physical chemistry.
Описание: Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Electrochemical and Mass Spectrometric Investigations of Biological Molecules" by Maurice Vincent Thompson, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.
A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals
Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates--especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors--into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry.
This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book.
Topics covered include:
Drug Approval Process and Regulatory Requirements (private standards)
Pharmacopeias and Compendial Approval Process (public standards)
Common methods in pharmaceutical analysis (typically compendial)
Common Calculations for assays and impurities and other specific tests
Analytical Method Validation, Verification, Transfer
Specifications including how to handle out of specification (OOS) and out of trend (OOT)
Impurities including organic, inorganic, residual solvents and elemental impurities
Good Documentation Practices for regulatory environment
Management of Analytical Laboratories
Analytical Instrument Qualifications including IQ, OQ, PQ and VQ
Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted.
Pharmaceutical Analysis for SmallMolecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.
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