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Small molecule drug discovery, 


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Цена: 17180.00р.
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Название:  Small molecule drug discovery
ISBN: 9780128183496
Издательство: Elsevier Science
Классификация:
ISBN-10: 0128183497
Обложка/Формат: Paperback
Страницы: 356
Вес: 0.74 кг.
Дата издания: 20.11.2019
Язык: English
Размер: 192 x 234 x 23
Подзаголовок: Methods, molecules and applications
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases.

The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.

  • Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery
  • Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics
  • Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches
  • Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules



Chemosensors of Ion and Molecule Recognition

Автор: J.P. Desvergne; A.W. Czarnik
Название: Chemosensors of Ion and Molecule Recognition
ISBN: 9401057591 ISBN-13(EAN): 9789401057592
Издательство: Springer
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Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Proceedings of the NATO Advanced Research Workshop on Chemosensors of Ion and Molecule Recognition, Bonas, France, August 31-September 4, 1996

Stimuli-Responsive Materials: From Molecules to Nature Mimicking Materials Design

Автор: Urban Marek W.
Название: Stimuli-Responsive Materials: From Molecules to Nature Mimicking Materials Design
ISBN: 1849736561 ISBN-13(EAN): 9781849736565
Издательство: Royal Society of Chemistry
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Цена: 18372.00 р.
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Описание: Covers the scientific principles, developments and recent technological advances of stimuli responsive materials for those new to and active in the field.

Design of Hybrid Molecules for Drug Development

Автор: Decker, Michael
Название: Design of Hybrid Molecules for Drug Development
ISBN: 0081010117 ISBN-13(EAN): 9780081010112
Издательство: Elsevier Science
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Цена: 24423.00 р.
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Описание:

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.

Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.

With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.

  • Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes
  • Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied
  • Compares the advantages and disadvantages of these compounds
  • Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

Автор: Postigo, Al
Название: Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
ISBN: 0128129581 ISBN-13(EAN): 9780128129586
Издательство: Elsevier Science
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Цена: 29476.00 р.
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Описание:

Late Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the author's expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.

  • Highlights the latest developments in the field in a concise volume
  • Provides details of key fluorinating reagents across diverse families of organic compounds
  • Explores the current applications and future potential of fluorine in drug development
Single molecule studies of nucleic acids and their associated proteins

Автор: Bensimon, David (research Director And Professor, Lps-ens, Psl, Cnrs And Department Of Chemistry And Biochemistry, Ucla, Usa) Croquette, Vincent (re
Название: Single molecule studies of nucleic acids and their associated proteins
ISBN: 0198530927 ISBN-13(EAN): 9780198530923
Издательство: Oxford Academ
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Цена: 11246.00 р.
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Описание: This book is an introduction to the novel physical tools that allow single molecule manipulation and visualisation. It describes the use of these tools to understand the elastic properties of single molecules of DNA and RNA and to study their interactions with the many proteins that process them.

Chemosensors of Ion and Molecule Recognition

Автор: J.P. Desvergne; A.W. Czarnik
Название: Chemosensors of Ion and Molecule Recognition
ISBN: 079234555X ISBN-13(EAN): 9780792345558
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The design and use of chemosensors for ion and molecule recognition have developed at an extraordinary rate. This area involves work at the interface of organic and inorganic chemistry, physical chemistry, biology, medicine and environmental science and is providing new sensors based on the specific signal delivered by the analyte-probe reaction.

Naphthalenediimide and Its Congeners: From Molecules to Materials

Автор: G. Dan Pantos
Название: Naphthalenediimide and Its Congeners: From Molecules to Materials
ISBN: 1849739226 ISBN-13(EAN): 9781849739221
Издательство: Royal Society of Chemistry
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Цена: 35693.00 р.
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Описание: Essential reference material for postdoctoral researchers and postgraduate students providing background information on naphthalenediimide chemistry.

Small Organic Molecules on Surfaces

Автор: Helmut Sitter; Claudia Draxl; Michael Ramsey
Название: Small Organic Molecules on Surfaces
ISBN: 3662520710 ISBN-13(EAN): 9783662520710
Издательство: Springer
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Цена: 18284.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: With state-of-the-art material on this fast-developing field of research, this presentation of organic chemistry`s promising applications in optoelectronics reflects the widely acknowledge need to understand interface formation, film growth and functionality.

Basic Stereochemistry of Organic Molecules

Автор: Rose Marie O. Mendoza
Название: Basic Stereochemistry of Organic Molecules
ISBN: 1774077922 ISBN-13(EAN): 9781774077924
Издательство: Mare Nostrum (Eurospan)
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Цена: 23423.00 р.
Наличие на складе: Нет в наличии.

Описание: Explores the various kinds of molecules in organic chemistry and the reactions that take place in them, mainly highlighting the manner in which they occur and the structure in which they can be found to exist.

Автор: Thomas Zell, Robert Langer
Название: Hydrogen Storage: Based on Hydrogenation and Dehydrogenation Reactions of Small Molecules
ISBN: 3110534606 ISBN-13(EAN): 9783110534603
Издательство: Walter de Gruyter
Цена: 26015.00 р.
Наличие на складе: Нет в наличии.

Описание: Hydrogen is believed to be the energy source of the future, enabling zero-emission and efficient production of power. This comprehensive publication presents a broad spectrum of various chemical aspects of hydrogen storage. The authors also address global climate change issues, carbon dioxide sequestration problems and CO 2 -based hydrogen storage.

Circularly Polarized Luminescence of Isolated Small Organic Molecules

Автор: Mori Tadashi
Название: Circularly Polarized Luminescence of Isolated Small Organic Molecules
ISBN: 9811523088 ISBN-13(EAN): 9789811523083
Издательство: Springer
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Цена: 20962.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book collects all the latest advances in the leading research of the circularly polarized luminescence (CPL) of small organic molecules.


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