The Imaging of Infection and Inflammation, P.H. Cox; J.R. Buscombe
Автор: P.H. Cox; J.R. Buscombe Название: The Imaging of Infection and Inflammation ISBN: 9401060940 ISBN-13(EAN): 9789401060943 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Evoked potentials (EPs) have been used for several decades to assess neurologic function intraoperatively and in outpatient studies. This is a modern, practical guide to performing these studies and interpreting the results. The book opens with an introductory chapter on the basic principles of EPs, and is followed by in-depth discussion of each clinical modality.
Автор: B. H. Waksman; T. Yonezawa; H. Lassmann Название: Inflammation and Demyelination in the Central Nervous System ISBN: 3540124209 ISBN-13(EAN): 9783540124207 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The present report, compares two murine models of virus induced chronic relapsing demyelination. MHV-induced demyelination in the BALB/c mouse results from the direct virus mediated cytolysis of oligodendrocytes. Extensive remyelination by oligodendrocytes is noted. Recurrent demyel- ination occurs in small areas. Infectious virus persists and 34 Fig. 2: Demyelination in SJL/J mice infected with TMEV. A) Multifocal areas of perivascular demyelination in the spinal cord (110 days post infection). Para- phenylene diamine stain. X 250. B) Perivascular inflammatory infiltration within the white matter of the spinal cord (22 days post infec- tion). Paraphenylene diamine stain. X600. C) Localization of TMEV associated antigen in the cytoplasm of oligodendrocytes (45 days post infec- tion). Vibratome section stained with the peroxidase-anti peroxidase technique. X 400. D) Immunoperoxidase staining of viral antigen within inner and outer loops of an oligodendrocyte (45 days post infectin) X 60,000. E) Longitudinal section showing viral antigen within Schmidt-Lanterman incisures (80 days post infection). X 49,000. viral antigens are localized within oligodendrocytes and their processes. TMEV-induced demyelination in SJL/J mice is asso- ciated with perivascular inflammatory infilrates and is dimin- ished by immunosuppressive measures. Remyelination by oligo- dendrocytes is delayed and incomplete. Chronic demyelination is widespread and associated with perivascular inflammatory infiltrates. The virus persists and viral antigen is local- ized within oligodendrocytes.
Автор: Elena Lazzeri; Alberto Signore; Paola Anna Erba; N Название: Radionuclide Imaging of Infection and Inflammation ISBN: 8847039274 ISBN-13(EAN): 9788847039278 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This atlas fills a gap in the literature by documenting in detail the role of nuclear medicine imaging of infection and inflammation. The pathophysiologic and molecular mechanisms on which radionuclide imaging of infection/inflammation is based are clearly explained, but the prime focus of the book is on the clinical relevance of such procedures. Their impact is demonstrated by a collection of richly illustrated teaching cases that describe the most commonly observed scintigraphic patterns, as well as anatomic variants and technical pitfalls. Due attention is paid to the application of recently developed techniques, including multimodality fusion imaging such as SPECT/CT and PET/CT. Emphasis is placed in particular on the ability of multimodality imaging to increase both the sensitivity and the specificity of radionuclide imaging. This atlas will be an excellent learning tool for residents in nuclear medicine and illuminating for other specialists with an interest in the field.
Автор: Gillespie, Stephen Bamford, Kathleen Название: Medical Microbiology and Infection at a Glance, 4th Edition ISBN: 0470655712 ISBN-13(EAN): 9780470655719 Издательство: Wiley Рейтинг: Цена: 4902.00 р. Наличие на складе: Поставка под заказ.
Описание: This concise and popular introduction to medical microbiology and infection encapsulates the fundamental facts and principles of this rapidly growing and changing subject area. Written by experienced clinicians and teachers, it covers the basic concepts o
Автор: John Playfair and Gregory Bancroft Название: Infection & Immunity Fourth Edition ISBN: 0199609500 ISBN-13(EAN): 9780199609505 Издательство: Oxford Academ Рейтинг: Цена: 9027.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gives a perfectly balanced overview of the field, describing the key infectious agents our bodies encounter and how our immune system responds to them. It also explains how diseases are spread and what measures we can take to control this spread, from vaccination to increasing public awareness.
Автор: Rakesh K. Gupta; Robert B. Lufkin Название: MR Imaging and Spectroscopy of Central Nervous System Infection ISBN: 1475705735 ISBN-13(EAN): 9781475705737 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Central nervous system (CNS) infections continue to pose a serious problem in health care even with improved knowledge and treatment. This work is an attempt to provide a comprehensive review of imaging and spectroscopy of the commonly encountered CNS infections in the clinical practice in developing and developed countries.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy.
Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections.
Presents the most advanced information regarding the role of the autophagic system in life and death
Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment
Includes chapters authored by leaders in the field around the globe--the broadest, most expert coverage available
Описание: In a fully revised second edition, this comprehensive review of clinical and experimental aspects of IL-17 and IL-22 and the cells that produce them covers the latest scientific advances, with additional chapters on processes such as receptor family signaling.
Описание: In a fully revised second edition, this comprehensive review of clinical and experimental aspects of IL-17 and IL-22 and the cells that produce them covers the latest scientific advances, with additional chapters on processes such as receptor family signaling.
Автор: Jeannette M. Potts Название: Genitourinary Pain and Inflammation: ISBN: 1493960792 ISBN-13(EAN): 9781493960798 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Any physician who sees men or women for signs or symptoms presenting below the umbilicus would appreciate this comprehensive text in which multiple subspecialists share their perspective with respect to organ-specific disorders as well as the myriad overlapping syndromes that may manifest as genitourinary (GU) inflammation or pain. Unlike other fields, the subspecialty of pain, particularly genitourinary or pelvic pain, suffers from the lack of objective data and the paucity of level 1 evidence-based studies. I recall an article about fibromyalgia read many years ago, in which the author stated, “the lack of level 1 evidence places a premium on the physician’s creativity.” Genitourinary Pain and Inflammation: Diagnosis and Management is a compilation of expert creativity and opinion based on critical review of the literature, consensus reports, and the authors’ professional experiences. Inflammation and pain caused by infectious etiologies are presented by experts in urological and gastrointestinal fields. Pain syndromes specific to the pelvic floor or genitourinary system are discussed from several perspectives: gynecology, rheumatology, urology, physical medicine, and psychiatry. We also include chapters addressing iatrogenic causes of GU inflammation, such as those caused by catheters, prosthetics, radiation, or chemotherapy. Management by means of pharmacological, surgical, or alternative methods is likewise considered within the context of specific disease entities, as well as within the separate therapeutic chapters.
Автор: Andrzej G?rski; Hubert Krotkiewski; Michal Zimecki Название: Inflammation ISBN: 9048158524 ISBN-13(EAN): 9789048158522 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: lnflammatory reactions are generated in response to extemal and intemal stimuli, such as infection, trauma, clinical insult or dysregulation of the umnune system. The int1ammatory responses may bc antigen-specific or non-specific, local or systemic, chronic or rapid and severe, characterized by a massive release of mediators, often lethal. The aim of this book is to review selectcd aspects associated with the mechanism of the pathology of int1ammatory processes of ditlerent origin and to evaluate therapeutic strategies aimed at combating various inflamma- tory diseases. The introductory article describcs the inmlllnological status of patients with severe sepsis, with particular attention paid to the roJe of circulating neutrophils. Intcgrin activation and chemokine receptor expression and the roles of IL-15, prostaglandins and leukotriens in inflmmnation and immunity are the subjects of next articles. Subsequent reviews are focused on allergic diseases involving mast cells and Th2 type cytokines, in particular the mech- anisms of atopic dennatitis and signaling hy IL-13. The intlmmnatory responscs elicited by Mycobacterium tuberculosis and Mvcobacferium nviwn are also analyzed with special interest paid to the mechanisms which allow the bacteria to escape the host' s immune reactions. The thcrapeutic potential of IL- I 0 in infection and inflammation and thc possible factors contributing to the devclopment of idiopathic pulmonary fibrosis are rcvicwed in the next articles. The final report demonstrates the advantages of bacteriophage ther- apy in thc context of the aggravating problem of hactcrial resistance to antibi- otics.
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. "Volume 8 Autophagy and Human Diseases," concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington s disease, Parkin s disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.
Considering that autophagy is associated with numerous biological processes including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.
Volumes in the Series
Volume 1: Molecular Mechanisms. Elucidates autophagy s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn s Disease, Gaucher Disease, Huntington s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and exec
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