Автор: Richard B. Silverman Название: The Organic Chemistry of Drug Design and Drug Action, ISBN: 0123820308 ISBN-13(EAN): 9780123820303 Издательство: Elsevier Science Рейтинг: Цена: 13304.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.
This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage.
This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.
Описание: The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development.
Автор: Daniel Lednicer Название: Strategies for Organic Drug Synthesis and Design ISBN: 0470190396 ISBN-13(EAN): 9780470190395 Издательство: Wiley Рейтинг: Цена: 25970.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints.
Автор: Nicholas Bodor,Peter Buchwald Название: Retrometabolic Drug Design and Targeting ISBN: 0470949457 ISBN-13(EAN): 9780470949450 Издательство: Wiley Рейтинг: Цена: 22643.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Innovative approach to drug design that`s more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively.
Автор: Sun Hongmao Название: A Practical Guide to Rational Drug Design ISBN: 0081000987 ISBN-13(EAN): 9780081000984 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.
Автор: Leff Название: Receptor - Based Drug Design ISBN: 0824701623 ISBN-13(EAN): 9780824701628 Издательство: Taylor&Francis Рейтинг: Цена: 26796.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Employing a range of examples from G-protein-coupled receptors and ligand-gated ion channels, this title illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design. It explains the experimental and theoretical methods used to characterize interactions between ligands and receptors.
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