Receptor Binding, Alan A. Boulton; Glen B. Baker; Pavel D. Hrdina

Автор: Anthony P. Davenport
Название: Receptor Binding Techniques
ISBN: 1493959360 ISBN-13(EAN): 9781493959365
Издательство: Springer
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Описание: The 3rd edition of this Methods in Molecular Biology (TM) book expands on classic and new methods and techniques for studying receptors in silico, in vitro and in vivo. Includes reagent and materials lists, laboratory protocols, troubleshooting tips and pitfalls.

Автор: F. Cattabeni
Название: Principles and Methods in Receptor Binding
ISBN: 147571579X ISBN-13(EAN): 9781475715798
Издательство: Springer
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Описание: " This NATO-ASI on "Principles and Methods in Receptor Binding" was devoted mainly to the following aspects of the study of receptors: the principles underlying the use of the binding technique;

Автор: Craig W. Stevens
Название: G Protein-Coupled Receptor Genetics
ISBN: 1627037780 ISBN-13(EAN): 9781627037785
Издательство: Springer
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Описание: G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field.

Автор: Chaohong Liu
Название: B Cell Receptor Signaling
ISBN: 1493974734 ISBN-13(EAN): 9781493974733
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This volume looks the current advanced protocols used to study aspects of the B cell receptor (BCR).

Автор: Zhixiang Wang
Название: ErbB Receptor Signaling
ISBN: 1493972189 ISBN-13(EAN): 9781493972180
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume contains protocols specifically designed for studying cell signaling mediated by ErbB receptors, all applicable to the study of a broad range of ErbB receptor-mediated signaling from basic research to clinic applications, from cultured cells to various animal models and primary cancer cells from patients.

Автор: Vincent Laudet
Название: The Nuclear Receptor FactsBook,
ISBN: 0124377351 ISBN-13(EAN): 9780124377356
Издательство: Elsevier Science
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Цена: 12464.00 р.
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Описание: Devoted to nuclear receptors, this work presents an introduction and describes the mode of action of the receptors in general. It also contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure; Isolation; DNA binding properties; Ligands; Expression; Target genes; Knockouts; and more.

Автор: Duarte Miguel F. Prazeres; Sofia Aires M. Martins
Название: G Protein-Coupled Receptor Screening Assays
ISBN: 1493923358 ISBN-13(EAN): 9781493923359
Издательство: Springer
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Описание: This volume explores the considerable efforts that have been directed towards the development of G Protein-Coupled Receptors (GPCR) screening assays in order to disclose GPCR acting compounds, elucidate signaling mechanisms or evaluate compound`s efficacy.

Автор: Mark P. Running
Название: G Protein-Coupled Receptor Signaling in Plants
ISBN: 1493962167 ISBN-13(EAN): 9781493962167
Издательство: Springer
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Цена: 14673.00 р.
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Описание: This Methods in Molecular Biology book describes techniques used in the study of small GTPases and related proteins. Includes a chapter on bioinformatics approaches, plus reproducible protocols, materials lists, practical tips and troubleshooting advice.

Автор: Craig W. Stevens
Название: G Protein-Coupled Receptor Genetics
ISBN: 1493963325 ISBN-13(EAN): 9781493963324
Издательство: Springer
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Цена: 16769.00 р.
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Описание: G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field.

Автор: Serena Germano
Название: Receptor Tyrosine Kinases
ISBN: 1493954490 ISBN-13(EAN): 9781493954490
Издательство: Springer
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Цена: 13275.00 р.
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Описание:

Part I: RTKs Activation and Signalling

1. Analysis of Receptor Tyrosine Kinase (RTK) Phosphorylation by Immunoblotting

Martina McDermott and Norma O'Donovan

2. Analysis of Changes in Phosphorylation of Receptor Tyrosine Kinases: Antibody Arrays

Sweta Rani and Lorraine O'Driscoll

3. Analysis of Epidermal Growth Factor Receptor Dimerization by BS³ Crosslinking

Harmony F. Turk and Robert S. Chapkin

4. Single-Molecule Optical Methods Analyzing Receptor Tyrosine Kinase Activation in Living Cells

Inhee Chung and Ira Mellman

5. Evaluation of the Dimerization Profiles of HER Tyrosine Kinases by Time-Resolved Fцrster Resonance Energy Transfer (TR-FRET)

Evelyne Lopez-Crapez, Alexandre Ho-Pun-Cheung, Patrick Garnero, and Hervй Bazin

6. Applying the Proximity Ligation Assay (PLA) to Mouse Preimplantation Embryos for Identifying Protein-Protein Interactions In Situ

Ivan Bedzhov and Marc P. Stemmler

Part II: RTKs Aberrant Expression

7. Analysis of Receptor Tyrosine Kinase Gene Amplification on the Example of FGFR1

Diana Boehm, Anne von Mдssenhausen, and Sven Perner

8. Quantification of the Effects of Mutations on Receptor Tyrosine Kinase (RTK) Activation in Mammalian Cells

Lijuan He and Kalina Hristova

Part III: RTKs Trafficking and Negative Regulation

9. Cell Surface Biotinylation of Receptor Tyrosine Kinases to Investigate Intracellular Trafficking

Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan

10. Studying N-Linked Glycosylation of Receptor Tyrosine Kinases

Harri M. Itkonen and Ian G. Mills

11. Identification of Receptor Protein Tyrosine Phosphatases (RPTPs) as Regulators of Receptor Tyrosine Kinases (RTKs) Using an RPTP siRNA-RTK Substrate Screen

Hojin Lee and Anton M. Bennett

12. Downregulation of Receptor Tyrosine Kinases Through Ubiquitination: Analysis by Immunodetection

Noriaki Shimokawa and Noriyuki Koibuchi

13. Regulation of Receptor Tyrosine Kinases by miRNA: Overexpression of miRNA Using Lentiviral Inducible Expression Vectors

XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai

Part IV: RTKs as Pharmacological Targets

14. Human Tumor Xenografts in Mouse as a Model for Evaluating Therapeutic Efficacy of Monoclonal Antibodies or Antibody-Drug Conjugate Targeting Receptor Tyrosine Kinases

Liang Feng, Wei Wang, Hang-Ping Yao, Jianwei Zhou, Ruiwen Zhang, and Ming-Hai Wang

15. Receptor Tyrosine Kinase Targeting in Multicellular Spheroids

Susan Breslin and Lorraine O'Driscoll

16. Receptor Tyrosine Kinases and Drug Resistance: Development and Characterization of In Vitro Models of Resistance to RTK Inhibitors

Claire Corcoran and Lorraine O'Driscoll

Автор: Martial Ruat
Название: The Smoothened Receptor in Cancer and Regenerative Medicine
ISBN: 3319354027 ISBN-13(EAN): 9783319354026
Издательство: Springer
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Описание: Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.