Principles and Methods in Receptor Binding, F. Cattabeni

Автор: Alan A. Boulton; Glen B. Baker; Pavel D. Hrdina
Название: Receptor Binding
ISBN: 0896030784 ISBN-13(EAN): 9780896030787
Издательство: Springer
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Автор: Lieberman Benjamin A.
Название: Steroid Receptor Methods / Protocols and Assays
ISBN: 0896037541 ISBN-13(EAN): 9780896037540
Издательство: Springer
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Описание: A distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.

Автор: Duarte Miguel F. Prazeres; Sofia Aires M. Martins
Название: G Protein-Coupled Receptor Screening Assays
ISBN: 1493923358 ISBN-13(EAN): 9781493923359
Издательство: Springer
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Описание: This volume explores the considerable efforts that have been directed towards the development of G Protein-Coupled Receptors (GPCR) screening assays in order to disclose GPCR acting compounds, elucidate signaling mechanisms or evaluate compound`s efficacy.

Автор: Craig W. Stevens
Название: G Protein-Coupled Receptor Genetics
ISBN: 1627037780 ISBN-13(EAN): 9781627037785
Издательство: Springer
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Цена: 23757.00 р.
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Описание: G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field.

Автор: R.B. Lichtner; R.N. Harkins
Название: EGF Receptor in Tumor Growth and Progression
ISBN: 3662033933 ISBN-13(EAN): 9783662033937
Издательство: Springer
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Цена: 12157.00 р.
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Описание: Beyond cell proliferation, activation of EGF receptor by its specific ligands controls important physiological processes, such as cell differentiation, apoptosis, cell migration, and cell shape.

Автор: Serena Germano
Название: Receptor Tyrosine Kinases
ISBN: 1493954490 ISBN-13(EAN): 9781493954490
Издательство: Springer
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Описание:

Part I: RTKs Activation and Signalling

1. Analysis of Receptor Tyrosine Kinase (RTK) Phosphorylation by Immunoblotting

Martina McDermott and Norma O'Donovan

2. Analysis of Changes in Phosphorylation of Receptor Tyrosine Kinases: Antibody Arrays

Sweta Rani and Lorraine O'Driscoll

3. Analysis of Epidermal Growth Factor Receptor Dimerization by BS³ Crosslinking

Harmony F. Turk and Robert S. Chapkin

4. Single-Molecule Optical Methods Analyzing Receptor Tyrosine Kinase Activation in Living Cells

Inhee Chung and Ira Mellman

5. Evaluation of the Dimerization Profiles of HER Tyrosine Kinases by Time-Resolved Fцrster Resonance Energy Transfer (TR-FRET)

Evelyne Lopez-Crapez, Alexandre Ho-Pun-Cheung, Patrick Garnero, and Hervй Bazin

6. Applying the Proximity Ligation Assay (PLA) to Mouse Preimplantation Embryos for Identifying Protein-Protein Interactions In Situ

Ivan Bedzhov and Marc P. Stemmler

Part II: RTKs Aberrant Expression

7. Analysis of Receptor Tyrosine Kinase Gene Amplification on the Example of FGFR1

Diana Boehm, Anne von Mдssenhausen, and Sven Perner

8. Quantification of the Effects of Mutations on Receptor Tyrosine Kinase (RTK) Activation in Mammalian Cells

Lijuan He and Kalina Hristova

Part III: RTKs Trafficking and Negative Regulation

9. Cell Surface Biotinylation of Receptor Tyrosine Kinases to Investigate Intracellular Trafficking

Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan

10. Studying N-Linked Glycosylation of Receptor Tyrosine Kinases

Harri M. Itkonen and Ian G. Mills

11. Identification of Receptor Protein Tyrosine Phosphatases (RPTPs) as Regulators of Receptor Tyrosine Kinases (RTKs) Using an RPTP siRNA-RTK Substrate Screen

Hojin Lee and Anton M. Bennett

12. Downregulation of Receptor Tyrosine Kinases Through Ubiquitination: Analysis by Immunodetection

Noriaki Shimokawa and Noriyuki Koibuchi

13. Regulation of Receptor Tyrosine Kinases by miRNA: Overexpression of miRNA Using Lentiviral Inducible Expression Vectors

XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai

Part IV: RTKs as Pharmacological Targets

14. Human Tumor Xenografts in Mouse as a Model for Evaluating Therapeutic Efficacy of Monoclonal Antibodies or Antibody-Drug Conjugate Targeting Receptor Tyrosine Kinases

Liang Feng, Wei Wang, Hang-Ping Yao, Jianwei Zhou, Ruiwen Zhang, and Ming-Hai Wang

15. Receptor Tyrosine Kinase Targeting in Multicellular Spheroids

Susan Breslin and Lorraine O'Driscoll

16. Receptor Tyrosine Kinases and Drug Resistance: Development and Characterization of In Vitro Models of Resistance to RTK Inhibitors

Claire Corcoran and Lorraine O'Driscoll

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 3662512238 ISBN-13(EAN): 9783662512234
Издательство: Springer
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Цена: 49631.00 р.
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Описание: This book offers up-to-date information on the molecular and functional properties and pharmacology of mammalian Transient Receptor Potential channels, from close-up views of single protein/channels to broader principles of function and important pathologies.

Автор: Zhixiang Wang
Название: ErbB Receptor Signaling
ISBN: 1493972189 ISBN-13(EAN): 9781493972180
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume contains protocols specifically designed for studying cell signaling mediated by ErbB receptors, all applicable to the study of a broad range of ErbB receptor-mediated signaling from basic research to clinic applications, from cultured cells to various animal models and primary cancer cells from patients.

Автор: Kim Neve
Название: Functional Selectivity of G Protein-Coupled Receptor Ligands
ISBN: 1493961160 ISBN-13(EAN): 9781493961160
Издательство: Springer
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Цена: 26120.00 р.
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Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.

Автор: Craig W. Stevens
Название: G Protein-Coupled Receptor Genetics
ISBN: 1493963325 ISBN-13(EAN): 9781493963324
Издательство: Springer
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Цена: 16769.00 р.
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Описание: G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field.

Автор: Foreman J.
Название: Textbook of Receptor Pharmacology
ISBN: 0849310296 ISBN-13(EAN): 9780849310294
Издательство: Taylor&Francis
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Цена: 13168.00 р.
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Описание: The bestselling first edition of Textbook of Receptor Pharmacology originated from a renowned course in receptor pharmacology taught at the University College of London for the past three decades. Its innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation.This edition streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors. Several chapters also contain problems for students to solve as well as worked-out solutions.The book contains over one hundred useful diagrams and tables to aid illustration of concepts and a helpful appendix explaining the simple mathematics used in the text. A time-saving resource and comprehensive textbook, Textbook of Receptor Pharmacology, Second Edition provides in-depth, up-to-date coverage of this