Parkinson`s Disease. From Clinical Aspects to Molecular Basis, Toshiharu Nagatsu; Hirotaro Narabayashi; Mitsuo Yo
Автор: Cristina Sampaio, Christopher G. Goetz... Название: Rating Scales in Parkinson`s Disease Clinical Practice and Research ISBN: 0199783101 ISBN-13(EAN): 9780199783106 Издательство: Oxford Academ Рейтинг: Цена: 12197.00 р. 17424.00-30% Наличие на складе: Есть (1 шт.) Описание: Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. Features Based on a consistent and uniform methodology A clear consolidation of material otherwise only available in journals The first comprehensive book of its kind
Описание: This book, authored by Gary A. Rosenberg, an authority on the physiology of brain fluids and metabolism, combines the classic physiology that dates back to the beginning of the nineteenth century with the advances in molecular sciences, providing a strong framework for understanding the diseases that are commonly treated by neurologists.
Автор: Gerhard Gr?nder Название: Molecular Imaging in the Clinical Neurosciences ISBN: 1493962183 ISBN-13(EAN): 9781493962181 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides readers with up-to-date information on the basic principles of molecular imaging and its major applications in clinical neuroscience. It includes key tips and expert guidance to ensure successful research results.
Автор: F. Gerstenbrand; Werner Poewe; G. Stern Название: Clinical Experiences with Budipine in Parkinson Therapy ISBN: 3540137645 ISBN-13(EAN): 9783540137641 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Some 20 years ago the introduction of levodopa opened a new era in the treatment of Parkinson's disease. Although levodopa remains the single most effective drug for the treatment of this maladie, challeng- ing therapeutic problems arise in many patients after several years of sustained treatment. Among these, fluctuations in motor performance and drug-induced involuntary movements are the most troublesome. The search for improved antiparkinsonian medications therefore con- tinues and important new developments have already occurred, for example the introduction of the dopaminergic ergots and the selective MAO-B-inhibitor selegeline (deprenyl) into routine treatment. The International Workshop on Parkinson's Disease held in Inns- bruckjIgls primarily considered a new compound with antiparkinsonian properties unrelated to any of the conventional drugs - the diphenyl- ex- piperidine compound budipine. The present volume records the perimental and clinical data on budipine presented at the meeting. The editors felt especially encouraged by the authorative biochemical, physiological, clinical and therapeutic reviews that were given at this symposium by outstanding experts in the field of extrapyramidal dis- orders. Their inclusion should make this volume a valuable source of information on a variety of current research aspects into Parkinson's disease. InnsbruckjLondon, October 1984 The Editors v Contents James Parkinson and the Treatment of His Disease. G. Stern ....
Описание: 1 2 3 O. D. Wiestler, U. Schlege1, andJ. Schramm lInstitut flir Neuropathologie, Universitatskliniken Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany 2Neurologische Universitatsklinik, Sigmund-Freud-Str. 25, 53127 Bonn, Germany 3Neurochirurgische Universitatsklinik, Sigmund-Freud-Str. 25,53127 Bonn, Germany In contrast to various other neoplastic disorders, there has still been no dramatic progress in the treatment of gliomas. Modem microsurgical and imaging techniques have made more tumors surgically accessible and have allowed a more extensive surgical resection. However, these new developments have not improved the clinical outcome. Recently, molecular biological studies on genes and genetic loci affected in tumors of the nervous system have yielded significant new insights into pathoge- netic machanisms. Many neuro-oncologists are therefore looking forward to transla- ting molecular genetic findings into novel diagnostic and therapeutic strategies for the management of these devastating neoplasms. We have produced this volume with the intention of highlighting major developments in both molecular and clinical neuro-oncology and of stimulating the communication and cooperation between these two fields. Two major families of growth-controlling genes have emerged from the past decade of intense research on the molecular genetics of tumors: oncogenes and tumor suppressor genes. Oncogenes are characterized by their potential to stimulate the growth of susceptible cells whereas tumor suppressor genes share a growth-inhibi- ting property. A stringently controlled interplay between these two regulatory me- chanisms is required to maintain a stable composition of tissues.
Автор: Derreumaux Philippe Название: Alzheimer`s Disease: Insights into Low Molecular Weight and ISBN: 1848167547 ISBN-13(EAN): 9781848167544 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer`s disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers` understanding of oligomerisation and fibril formation.
Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Автор: Keith A. Foster Название: Molecular Aspects of Botulinum Neurotoxin ISBN: 1461494532 ISBN-13(EAN): 9781461494539 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins.
Автор: Keith A. Foster Название: Molecular Aspects of Botulinum Neurotoxin ISBN: 1493951793 ISBN-13(EAN): 9781493951796 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins.
Автор: Kuei-Yuan Tseng Название: Cortico-Subcortical Dynamics in Parkinson`s Disease ISBN: 1617378836 ISBN-13(EAN): 9781617378836 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book assembles all that is currently known about the pathophysiological changes underlying Parkinson`s Disease (PD). It integrates key aspects of current PD knowledge and research, and provides critical reviews about mechanisms of neurodegeneration.
Автор: Donald H. Gilden; Howard L. Lipton Название: Clinical and Molecular Aspects of Neurotropic Virus Infection ISBN: 1461289351 ISBN-13(EAN): 9781461289357 Издательство: Springer Рейтинг: Цена: 41787.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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