Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors, C. Marescaux; M. Vergnes; R. Bernasconi

Автор: Hanns M?hler
Название: Pharmacology of GABA and Glycine Neurotransmission
ISBN: 3642631916 ISBN-13(EAN): 9783642631917
Издательство: Springer
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Цена: 12577.00 р.
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Описание: With contributions by numerous experts

Автор: Adam C. Errington; Giuseppe Di Giovanni; Vincenzo
Название: Extrasynaptic GABAA Receptors
ISBN: 1493914251 ISBN-13(EAN): 9781493914258
Издательство: Springer
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Цена: 20962.00 р.
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Описание: GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Автор: Jaime M. Monti; Seithikurippu Ratnas Pandi-Perumal
Название: GABA and Sleep
ISBN: 3034807406 ISBN-13(EAN): 9783034807401
Издательство: Springer
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Цена: 28732.00 р.
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Описание: GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.

Автор: Adam C. Errington; Giuseppe Di Giovanni; Vincenzo
Название: Extrasynaptic GABAA Receptors
ISBN: 1493953214 ISBN-13(EAN): 9781493953219
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA.