Автор: Escors Название: Lentiviral Vectors and Gene Therapy ISBN: 3034804016 ISBN-13(EAN): 9783034804011 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.
Описание: This volume provides current methods and protocols for geneand protein delivery based on both lentivirus-generated and spontaneouslyreleased nanovesicles. Lentiviral Vectors and Exosomes as Gene andProtein Delivery Tools guides readers through methods on macromoleculedelivery and chapters describe the LV-based protocols of gene engineering. Written in thehighly successful Methods in Molecular Biology series format, chaptersinclude introductions to their respective topics, lists of the necessarymaterials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Lentiviral Vectors andExosomes as Gene and Protein Delivery Tools aims to ensure successfulresults in the further study of this vital field.
Описание: * Covers a new approach to gene therapy with a greatly improved safety profile * Complete coverage of the topic including molecular basis, production and biomedical applications * Has a wide audience including everyone who is directly or indirectly involved in the development of gene therapies .
Автор: Merten Название: Viral Vectors for Gene Therapy ISBN: 161779094X ISBN-13(EAN): 9781617790942 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular Biology™ series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.
Автор: Didier Trono Название: Lentiviral Vectors ISBN: 364262667X ISBN-13(EAN): 9783642626678 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For the first time a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.
Автор: Fleisch Название: A Student`s Guide to Vectors and Tensors ISBN: 0521171903 ISBN-13(EAN): 9780521171908 Издательство: Cambridge Academ Рейтинг: Цена: 4118.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Adopting the same approach used in his highly popular A Student`s Guide to Maxwell`s Equations, Fleisch explains vectors and tensors in plain language to give undergraduate and beginning graduate students a better understanding of how to use vectors and tensors to solve problems in physics and engineering.
Описание: The field of gene therapy has undergone remarkable advances, promising to impact human healthcare in the 21st century. This book provides methods for the processing and characterization of viral and non-viral gene transfer vectors, as well as promising approaches to design vectors for efficient, targeted and regulated gene delivery and expression.
Описание: Describes methods for the production of viral and non-viral gene transfer vectors, as well as protocols for critical applications in stem cell biology, cancer, diabetes, HIV and tissue engineering.
Автор: Vadim Yurinsky Название: Sums and Gaussian Vectors ISBN: 3540603115 ISBN-13(EAN): 9783540603115 Издательство: Springer Рейтинг: Цена: 6282.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Surveys the methods applied to study sums of infinite-dimensional independent random vectors in situations where their distributions resemble Gaussian laws. This book covers probabilities of large deviations, Chebyshev-type inequalities for seminorms of sums, and a method of constructing Edgeworth-type expansions.
Автор: Kenneth Palmer; Yuri Gleba Название: Plant Viral Vectors ISBN: 3642408281 ISBN-13(EAN): 9783642408281 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This wide-ranging review shows how far our understanding of plant viral vectors has come, with experts in `vectorology` contributing chapters on their work applying the science to cutting-edge techniques in genetics, nanotechnology, and other fields.
Автор: Sven Klimpel; Heinz Mehlhorn Название: Bats (Chiroptera) as Vectors of Diseases and Parasites ISBN: 3642393322 ISBN-13(EAN): 9783642393327 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Bats (Chiroptera) as Vectors of Diseases and Parasites
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