Signal Transduction and the Coordination of B Lymphocyte Development and Function II, Louis B. Justement; Katherine A. Siminovitch
Автор: Kalyuzhny Название: Signal Transduction Immunohistochemistry ISBN: 1617790230 ISBN-13(EAN): 9781617790232 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Unlike detecting constitutively expressed targets, immunohistochemical detection of labile, low abundance, and short-lived signal transduction molecules can be a very difficult task. In Signal Transduction Immunohistochemistry: Methods and Protocols, IHC experts contribute detailed protocols addressing the numerous challenges of signal-transduction immunohistochemistry (ST-IHC). Beginning with a set of introductory chapters, the volume moves on to cover techniques used for the preservation of antigens and their unmasking, protocols in digital imaging and image analysis of stained cells and tissues, high-throughput data collection and data analysis, and techniques used in neuroscience as well as cancer and stem cell research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Signal Transduction Immunohistochemistry: Methods and Protocols serves as an ideal guide for novices and as a bastion of inspiring ideas to be exploited by experienced researchers on the lookout for new experimental tricks and hints.
Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.
Описание: It includes a model for the T cell receptor interaction with a complex of MHC plus antigen, structure of y c`i T cell receptor and their distinct isotypic forms, the role of zeta chain in the expression and structure of T cell receptors and its role in transmembrane signalling.
Описание: The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep- ertoire of B cells that has the ability to recognize an almost un- limited array of foreign antigens.
Описание: This volume provides a review of current research in the field of B cell development and differentiation with particular emphasis on signal transduction processes.
Описание: Provides a review of research in the field of B cell development and differentiation with particular emphasis on signal transduction processes. This book focuses on the biochemical pathways which regulate B cell biology and the role of signal transduction processes in regulating various aspects of B cell function, development and differentiation.
Автор: Constantine Tsoukas Название: Lymphocyte Signal Transduction ISBN: 1489990135 ISBN-13(EAN): 9781489990136 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Signal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated by inter- and intra-molecular interactions, as well as by various post-translational modifications, lead to the activation of transcription factors that mediate cellular differentiation and growth, effector cell functions, and apoptotic cell death. Several investigators from various parts of the world convened at the 3rd Lymphocyte Signal Transduction Workshop in Crete, Greece from May 27 to June 1, 2005 to discuss their most recent findings in leukocyte signaling. This volume represents a collection of topics discussed during the conference.
Автор: Cornelis Murre Название: Epigenetic Regulation of Lymphocyte Development ISBN: 3642447678 ISBN-13(EAN): 9783642447679 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
Автор: Harinder Singh; Rudolf Grosschedl Название: Molecular Analysis of B Lymphocyte Development and Activation ISBN: 3642421881 ISBN-13(EAN): 9783642421884 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation.- Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination.- Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development.- Biochemistry of V(D)J Recombination.- The Pre-B Cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms.- Transcriptional Control of B Cell Activation.-Expression of MHC II Genes.- Class Switch Recombination: An Emerging Mechanism.- Blimp-1, Immunoglobulin Secretion, and the Switch to Plasma Cells.- Wnt Signaling in Lymphopoiesis.- Subject Index
Автор: E. Wecker; I. Horak Название: Retrovirus Genes in Lymphocyte Function and Growth ISBN: 3642683711 ISBN-13(EAN): 9783642683718 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: All but one* of the following articles represent comprehensive reports on a workshop held between 7 and 9 May 1981 at the Institute of Virology and Immunobiology, University of Wfuzburg, Federal Republic of Germany.
Автор: Sudhir Gupta; William E. Paul; Max D. Cooper; Elle Название: Mechanisms of Lymphocyte Activation and Immune Regulation III ISBN: 1468459457 ISBN-13(EAN): 9781468459456 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Third International Conference on Lymphocyte Activation and Immune Regulation, held in Newport Beach, California, February 16--18, 1990
Автор: Sudhir Gupta; Thomas Waldmann Название: Mechanisms of Lymphocyte Activation and Immune Regulation IV ISBN: 1461365007 ISBN-13(EAN): 9781461365006 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation.
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