Protein Folding Kinetics, Bengt N?lting

Автор: L. P. Pitaevskii
Название: Physical Kinetics,
ISBN: 0750626356 ISBN-13(EAN): 9780750626354
Издательство: Elsevier Science
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Описание: This volume is mainly concerned with a systematic development of the theory of plasmas, the authority being firmly rooted in the pioneering work of Landau. Corresponding rewsults are also given for partially ionized plasmas, relativistic, degenerate or non-ideal plasmas, and solid state plasmas.

Автор: Daniel L. Purich
Название: Enzyme Kinetics and Mechanism, Part F: Detection and Characteriza
ISBN: 0121822575 ISBN-13(EAN): 9780121822576
Издательство: Elsevier Science
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Описание: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with mo than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Автор: M. Albert Vannice
Название: Kinetics of Catalytic Reactions
ISBN: 1441937587 ISBN-13(EAN): 9781441937582
Издательство: Springer
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Описание: Describes how to conduct kinetic experiments with heterogeneous catalysts, analyze and model the results, and characterize the catalystsDetailed analysis of mass transfer in liquid phase reactions involving porous catalysts.

Автор: Paul C. Engel
Название: Enzyme Kinetics
ISBN: 0412239701 ISBN-13(EAN): 9780412239700
Издательство: Springer
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Описание: The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the fron tiers of his discipline.

Автор: Sadruddin Benkadda; George M. Zaslavsky
Название: Chaos, Kinetics and Nonlinear Dynamics in Fluids and Plasmas
ISBN: 3662142023 ISBN-13(EAN): 9783662142028
Издательство: Springer
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Описание: Over the last few years it has become apparent that fluid turbulence shares many common features with plasma turbulence, such as coherent structures and self-organization phenomena, passive scalar transport and anomalous diffusion.

Автор: Mischi
Название: Quantification of Contrast Kinetics in Clinical Imaging
ISBN: 3319646370 ISBN-13(EAN): 9783319646374
Издательство: Springer
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Описание: This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.

Автор: L. Liberti; F.G. Helfferich
Название: Mass Transfer and Kinetics of Ion Exchange
ISBN: 9400969015 ISBN-13(EAN): 9789400969018
Издательство: Springer
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Описание: Post-Conference Proceedings of the NATO Advanced Study on Mass Transfer and Kinetics of Ion Exchange, Maratea, Italy, May 31-June 11, 1982

Автор: Wilfried Litz
Название: Bench Scale Calorimetry in Chemical Reaction Kinetics
ISBN: 3319125311 ISBN-13(EAN): 9783319125312
Издательство: Springer
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Описание: This book describes new and efficient calorimetric measurement methods, which can be used to accurately follow the chemical kinetics of liquid phase reaction systems.

Автор: Swati Nagar; Upendra A. Argikar; Donald J. Tweedie
Название: Enzyme Kinetics in Drug Metabolism
ISBN: 1493960466 ISBN-13(EAN): 9781493960460
Издательство: Springer
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine