Описание: Discusses various aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. This book explains the principles and applications of techniques used in the field of molecular genetics. It also translates molecular genetics into cancer diagnosis.
Название: FISH (Fluorescence in Situ Hybridization) ISBN: 0199638845 ISBN-13(EAN): 9780199638840 Издательство: Oxford Academ Рейтинг: Цена: 19008.00 р. Наличие на складе: Поставка под заказ.
Описание: FISH (Fluorescence In Situ Hybridization) is a versatile technique that is constantly being applied to branches of research. With over 100 protocols, this book will be of significant interest to students and technicians in both clinical service and basic science laboratories who employ genetic or genomic technologies.
Автор: Liehr Название: Fluorescence In Situ Hybridization (FISH) ISBN: 3662529572 ISBN-13(EAN): 9783662529577 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This manual offers detailed protocols for fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches, which have been successfully used to study various aspects of genomic behavior and alterations. Methods using different probe and cell types, tissues and organisms, such as mammalians, fish, amphibians (including lampbrush-chromosomes), insects, plants and microorganisms are described in 57 chapters. In addition to multicolor FISH procedures and special applications such as the characterization of marker chromosomes, breakpoints, cryptic aberrations, nuclear architectures and epigenetic changes, as well as comparative genomic hybridization studies, this 2nd edition describes how FISH can be combined with other techniques. The latter include immunostaining, electron microscopy, single cell electrophoresis and microdissection. This well-received application guide provides essential protocols for beginning FISHers and FISH experts alike working in the fields of human genetics, microbiology, animal and plant sciences.
Автор: Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar Название: Chemical Biology of Nucleic Acids ISBN: 3642544517 ISBN-13(EAN): 9783642544514 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
Описание: This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications.
Описание: Discusses various aspects of immunohistochemistry and in situ hybridization technologies and the role they play in reaching a cancer diagnosis. This work provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, and the benefits and limitations of each method.
Автор: Joanna M. Bridger; Keith Morris Название: Fluorescence in situ Hybridization (FISH) ISBN: 1493957244 ISBN-13(EAN): 9781493957248 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Fluorescence in situ Hybridization (FISH) belongs to that special category of well-established molecular biology techniques that, since their inception a few decades ago, have succeeded in keeping a prominent position within the constantly expanding list of laboratory pro- dures for biomedical research and clinical diagnostics. The design simplicity and cost-effectiveness of the early FISH protocols, combined with the signifcant acceleration of discoveries in related technical areas such as fuor- cence microscopy, digital imaging, and nucleic acid technology have prompted the div- sifcation of the original technique into an outstanding number of imaginative and useful applications, and thus have not only held back its outmoding but have also promoted its expansion into different areas of basic and applied research in the post-genomic era. The 34 chapters included in this book aim at portraying the vibrant complexity and diversity of the current FISH protocol landscape, providing cutting-edge examples of va- ous applications for genetic and developmental research, cancer research, reproductive medicine, diagnostic and prognostic purposes, microbial ecology, and evolutionary st- ies. The book is divided in four parts: (I) Core Techniques, (II) Technical Advancements and Novel Adaptations, (III) Translational FISH: Applications for Human Genetics and Medicine, and (IV) Protocols for Model Organisms.
Автор: Ashley T. Haase; Michael B.A. Oldstone Название: In Situ Hybridization ISBN: 3642744273 ISBN-13(EAN): 9783642744273 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading researchers present contemporary treatment of in situ hybridization applied to current issues in animal virus pathogenesis. The genetic programs played out in these cells and the newer methods of hybridization at the electron microscopic level provide valuable insight into the complexities of virus-host interaction.
Автор: Diponkar Banerjee; Sohrab P. Shah Название: Array Comparative Genomic Hybridization ISBN: 1493959557 ISBN-13(EAN): 9781493959556 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book explores the scope of what is possible today in documenting abnormalities associated with several human cancers. Offers materials and reagents lists, step-by-step protocols, troubleshooting tips, pitfalls and more.
Автор: Boye Schnack Nielsen Название: In Situ Hybridization Protocols ISBN: 1493955268 ISBN-13(EAN): 9781493955268 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Situ Hybridization Protocols, Fourth Edition contains 21 protocols that utilize the in situ hybridization technology to document or take advantage of the visualization of specific RNA molecules.
Автор: G.R. Coulton; J. de Belleroche Название: In Situ Hybridization: Medical Applications ISBN: 940105326X ISBN-13(EAN): 9789401053266 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In situ hybridization has developed as a means of localizing specific DNA and RNA sequences within tissues. Complementary DNA, RNA or oligonucleotide probes, suitably labelled, are hybridized to specific DNA or RNA targets within tissues.
Описание: This Methods in Molecular Biology book details approaches for the detection of DNA and RNA including recovery of trace amounts of DNA for amplification and analysis, new qPCR chemistries, step-by-step, reproducible protocols, materials lists, tips and more.
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