A. Michael Lincoff Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease 9781617374081

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Автор: A. Michael Lincoff
Название: Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease
ISBN: 9781617374081
Издательство: Springer
Классификация:

Сердечно-сосудистая медицина

ISBN-10: 1617374083
Обложка/Формат: Paperback
Страницы: 476
Вес: 0.84 кг.
Дата издания: 09.11.2010
Серия: Contemporary Cardiology
Язык: English
Размер: 254 x 178 x 25
Основная тема: Medicine & Public Health
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: One of the most important developments in the field of cardiovascular medicine over the last two decades has been recognition of the key role played by arterial thrombosis in the pathogenesis of acute coronary syndromes, ischemic complications of percutane- ous coronary revascularization, and coronary and peripheral atherosclerosis. The phar- macologic armamentarium directed against vascular thrombosis has thus expanded substantially during that time, with development of new fibrinolytic agents, low-molecu- lar-weight heparins, direct thrombin inhibitors, antagonists to platelet activation, and the platelet glycoprotein lIb/IlIa inhibitors. Though clinical investigations of these com- pounds have been marked by failures as well as successes, there is little doubt that enhanced antithrombotic therapies have markedly improved the outcome of patients undergoing coronary revascularization or with acute coronary syndromes. Glycoprotein IIblIlIa receptor antagonists were introduced into clinical practice to overcome the limitations of approaches that inhibit only individual pathways of platelet activation. Multiple mechanisms of platelet activation in response to different agonists converge on the platelet membrane glycoprotein IIblIlIa complex, the final common pathway of platelet aggregation. The clinical hemorrhagic syndrome caused by a rare inherited defect in this receptor (Glanzmann s thrombasthenia), characterized by muco- cutaneous and postsurgical bleeding, but infrequent spontaneous organ (particularly central nervous system) bleeding, suggested that therapeutic inhibition of this receptor might be a potent, yet well-tolerated means of treating thrombotic disorders.

Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease, A. Michael Lincoff