Multiple Analyses in Clinical Trials, Lemuel A. Moy?
Автор: Lawrence M. Friedman; Curt D. Furberg; David L. De Название: Fundamentals of Clinical Trials ISBN: 3319307738 ISBN-13(EAN): 9783319307732 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Поставка под заказ.
Описание: This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.
Автор: Takashi Sozu; Tomoyuki Sugimoto; Toshimitsu Hamasa Название: Sample Size Determination in Clinical Trials with Multiple Endpoints ISBN: 3319220047 ISBN-13(EAN): 9783319220048 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1.Introduction.- 2.Continuous Co-primary Endpoints.- 3.Binary Co-primary Endpoints.- 4.Convenient Sample Size Formula.- 5.Continuous Primary Endpoints.- 6. Further Developments.- A.Sample Size Calculation Using other Contrasts for Binary Endpoints.- B.Empirical Power for Sample Size Calculation for Binary Co-primary Endpoints.- C.Numerical Tables for Ck in the Convenient Sample Size Formula for the Three Co-primary Continuous Endpoints Cace.- D.Software Programs for Sample Size Calculation for Continuous Co-primary Endpoints.- References.
Автор: Hans Scheurlen; Richard Kay; Michael Baum Название: Cancer Clinical Trials ISBN: 3642834213 ISBN-13(EAN): 9783642834219 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The meeting was generously supported again by the Federal Ministry of Research and Technology (Bundesministe rium flir Forschung und Technologie, BMFT) within the framework of the West German BMFT Breast Cancer Study Group.
Автор: Thomas Ondra Название: Optimized Response-Adaptive Clinical Trials ISBN: 3658083433 ISBN-13(EAN): 9783658083434 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small.
The papers in this volume represent a broad, applied swath of advanced contributions to the 2015 ICSA/Graybill Applied Statistics Symposium of the International Chinese Statistical Association, held at Colorado State University in Fort Collins. The contributions cover topics that range from statistical applications in business and finance to applications in clinical trials and biomarker analysis. Each papers was peer-reviewed by at least two referees and also by an editor. The conference was attended by over 400 participants from academia, industry, and government agencies around the world, including from North America, Asia, and Europe.
Автор: Zhen Chen; Aiyi Liu; Yongming Qu; Larry Tang; Nait Название: Applied Statistics in Biomedicine and Clinical Trials Design ISBN: 3319126938 ISBN-13(EAN): 9783319126937 Издательство: Springer Рейтинг: Цена: 26552.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The peer-reviewed contributions were solicited and selected from some 400 presentations at the annual meeting of the International Chinese Statistical Association (ICSA), held with the International Society for Biopharmaceutical Statistics (ISBS).
Автор: Jozef Nauta Название: Statistics in Clinical Vaccine Trials ISBN: 3642441912 ISBN-13(EAN): 9783642441912 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. With many worked-out real-life examples, its scope is more practical than theoretical.
Автор: Takashi Daimon; Akihiro Hirakawa; Shigeyuki Matsui Название: An Introduction to Dose-Finding Methods in Early Phase Clinical Trials ISBN: 4431555846 ISBN-13(EAN): 9784431555841 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs.
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