An analysis of two heuristic strategies for the development of mechanistic models, illustrated with historical examples from the life sciences.
In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in divergent explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility -- the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized.
When Discovering Complexity was originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993.
Описание: Presents 20 years of work at the North Temperate Lakes Long-Term Research Site. This site-synthesis volume provides the information base for the ecology of temperate lakes, and a general assessment of the role of lakes within their landscapes. It is of interest to American limonologists and general ecologists.
Автор: Yoshikuni Mizuno; Abraham Fisher; Israel Hanin Название: Mapping the Progress of Alzheimer`s and Parkinson`s Disease ISBN: 1475709730 ISBN-13(EAN): 9781475709735 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1h The 5 International Conference on the Progress in Alzheimer`s Disease and Parkinson`s 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium.
Автор: Edward K. L. Chan; Marvin J. Fritzler Название: Ten Years of Progress in GW/P Body Research ISBN: 1493902512 ISBN-13(EAN): 9781493902514 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.
Автор: Braga Название: Atomic Force Microscopy in Biomedical Research ISBN: 1617791040 ISBN-13(EAN): 9781617791048 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With its ability to explore the surface of the sample by means of a local scanning probe and its use of dedicated software allows to be visualize results, atomic force microscopy (AFM) has revolutionized the study of the smallest aspects of life. Atomic Force Microscopy in Biomedical Research: Methods and Protocols proves that this technology is no longer simply just another form of microscopy but has given rise to a completely new way of using microscopy that fulfils the dreams of all microscopists: being able to touch, move, and interact with the sample while it is being examined, thus making it possible to discover not only morphological but also chemical and physical structural information. Covering such topics as molecule imaging, nanoscale surface analysis and cellular imaging, force-spectroscopy, investigating drug action, and AFM as a nanotool, this volume features the most up-to-date techniques currently in use. Written in the Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and expert tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Atomic Force Microscopy in Biomedical Research: Methods and Protocols brings together different types of applications in order to provide examples from diverse fields in the hope of inspiring researchers to apply their ingenuity in their own specialization and add significant originality to their varying studies.
Описание: Proceedings of the Second International Conference held in Kyoto, Japan, November 6-10, 1989
Автор: Chaim Hershko; Abraham M. Konijn; Philip Aisen Название: Progress in Iron Research ISBN: 1461360900 ISBN-13(EAN): 9781461360902 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The 4th International Conference on Hemochromatosis and the 11th International Conference on Iron and Iron Proteins took place in Jerusalem on April 27 -30 and on May 2 -7 1993, respectively.
Автор: Willig Michael R., Walker Lawrence R. Название: Long-Term Ecological Research: Changing the Nature of Scientists ISBN: 019938021X ISBN-13(EAN): 9780199380213 Издательство: Oxford Academ Рейтинг: Цена: 13939.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Long-Term Ecological Research (LTER) Program is, in a sense, an experiment to transform the nature of science, and represents one of the most effective mechanisms for catalyzing comprehensive site-based research that is collaborative, multidisciplinary, and long-term in nature. The scientific contributions of the Program are prodigious, but the broader impacts of participation have not been examined in a formal way. This book captures the consequences of participation in the Program on the perspectives, attitudes, and practices of environmental scientists. The edited volume comprises three sections. The first section includes two chapters that provide an overview of the history, goals, mission, and inner workings of the LTER network of sites. The second section comprises three dozen retrospective essays by scientists, data managers or educators who represent a broad spectrum of LTER sites from deserts to tropical forests and from arctic to marine ecosystems. Each essay addresses the same series of probing questions to uncover the extent to which participation has affected the ways that scientists conduct research, educate students, or provide outreach to the public. The final section encompasses 5 chapters, whose authors are biophysical scientists, historians, behavioral scientists, or social scientists. This section analyzes, integrates, or synthesizes the content of the previous chapters from multiple perspectives and uncovers emergent themes and future directions.
Автор: Clymo Название: Reporting Research ISBN: 1107640466 ISBN-13(EAN): 9781107640467 Издательство: Cambridge Academ Рейтинг: Цена: 3960.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Want to learn how to present your research successfully? This concise guide offers step-by-step advice to help you write scientific articles, prepare posters and talks, and develop a critical attitude towards your own work as well as that of your colleagues. A must-read for graduates and postdoctoral scholars in biology.
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