Автор: Andrea Manni; Michael Verderame Название: Selective Estrogen Receptor Modulators ISBN: 1468496654 ISBN-13(EAN): 9781468496659 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs.
Автор: Antonio Cano; Joacquim Calaf i Alsina; Jose Luis D Название: Selective Estrogen Receptor Modulators ISBN: 3642445527 ISBN-13(EAN): 9783642445521 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.
Автор: Jordan V Craig Название: Estrogen Action, Selective Estrogen Receptor Modulators and ISBN: 1848169574 ISBN-13(EAN): 9781848169579 Издательство: World Scientific Publishing Рейтинг: Цена: 26928.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Presents the evolution of the authors` ideas about estrogen action and its modulation by a fresh group of drugs called SERMs (Selective Estrogen Receptor Modulators). This title presents a journey over years of discovery and success in advancing women`s health, with the prospect of improved medicinal chemistry for the future.
Автор: K. Lissak Название: Hormones and Brain Function ISBN: 1468420097 ISBN-13(EAN): 9781468420098 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Technically, the Congress was organized by the Hungarian Physiological Society in cooperation with the Federation of Hungarian Medical Societies in the building of the Hungarian Academy of Sciences.
Автор: Niels Bergemann; Anita Riecher-R?ssler Название: Estrogen Effects in Psychiatric Disorders ISBN: 3709117070 ISBN-13(EAN): 9783709117071 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A number of studies, mostly focusing on estrogen replacement therapy in women, have reported beneficial actions of these hormones on various neurobiological and neuropathological parameters in health and disease.
Автор: Kathleen M. Eyster Название: Estrogen Receptors ISBN: 1493931261 ISBN-13(EAN): 9781493931262 Издательство: Springer Рейтинг: Цена: 17468.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume examines a wide array of vital technologies for advancing our understanding of the receptor-mediated actions of estrogen. The protocols in this book range from standard methods and vital laboratory workhorses, such as receptor binding assays and western blot, to newer technologies such as RNAseq and proximity ligation assay. Chapters also discuss protocols from a broad range of tissue types to demonstrate the variety of estrogen receptor effects. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Estrogen Receptors: Methods and Protocols is a detailed and helpful resource for scientists who are intrigued by the many facets of estrogen.
The chapter 'Bioinformatics Analysis of Estrogen-Responsive Genes' is open access under a CC BY 4.0 license.
Автор: Kenneth S. Korach; Tim Wintermantel Название: Tissue-Specific Estrogen Action ISBN: 3642421032 ISBN-13(EAN): 9783642421037 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.
Описание: The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient.
Автор: Antonio Giuditta; Claire Zomzely-Neurath; Barry B. Название: Role of RNA and DNA in Brain Function ISBN: 1461294274 ISBN-13(EAN): 9781461294276 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There was once an old Chinese man working on a hill with a boy. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric.
Описание: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain.
An introduction to the brain's anatomical organization and functions with explanations in terms of evolutionary adaptations and development.
This introduction to the structure of the central nervous system demonstrates that the best way to learn how the brain is put together is to understand something about why. It explains why the brain is put together as it is by describing basic functions and key aspects of its evolution and development. This approach makes the structure of the brain and spinal cord more comprehensible as well as more interesting and memorable. The book offers a detailed outline of the neuroanatomy of vertebrates, especially mammals, that equips students for further explorations of the field.
Gaining familiarity with neuroanatomy requires multiple exposures to the material with many incremental additions and reviews. Thus the early chapters of this book tell the story of the brain's origins in a first run-through of the entire system; this is followed by other such surveys in succeeding chapters, each from a different angle. The book proceeds from basic aspects of nerve cells and their physiology to the evolutionary beginnings of the nervous system to differentiation and development, motor and sensory systems, and the structure and function of the main parts of the brain. Along the way, it makes enlightening connections to evolutionary history and individual development. Brain Structure and Its Origins can be used for advanced undergraduate or beginning graduate classes in neuroscience, biology, psychology, and related fields, or as a reference for researchers and others who want to know more about the brain.
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