Molecular Aspects of Oxidative Drug Metabolizing Enzymes, Emel Arinc; John B. Schenkman; Ernest Hodgson
Автор: Emel Arin?; John B. Schenkman; Ernest Hodgson Название: Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes ISBN: 0306460483 ISBN-13(EAN): 9780306460487 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997
Автор: Armstrong Donald Название: Oxidative Stress Biomarkers and Antioxidant Protocols ISBN: 0896038505 ISBN-13(EAN): 9780896038509 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.
Описание: This book reviews and discusses knowledge gathered on Metabolic Syndrome and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. It focuses on recent discoveries and progress toward possible therapeutic strategies.
Автор: R.C. Cutler; L. Packer; J. Bertram; A. Mori Название: Oxidative Stress and Aging ISBN: 3034873395 ISBN-13(EAN): 9783034873390 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age- related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi- cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter- national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.
Автор: Sami Ahmad Название: Oxidative Stress and Antioxidant Defenses in Biology ISBN: 1461596912 ISBN-13(EAN): 9781461596912 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The ground-state of molecular oxygen, O, is essential to many 2 indispensible metabolic processes of all aerobic life forms ranging from prokaryotes, protists, plants, and fungi to animals. Research by mammalian toxicologists and clinicians has unravelled persua- sive evidence that O dependence imposes universal toxicity to all 2 aerobic life processes. The basis of this paradox is that one-electron reduction of O2 generates the superoxide anion free radical, 0;-, from numerous biological sources; for example, redox-active autoxidizable molecules such as catecholamines, oxidoreductases, and subcellular organelles such as mitochondria, endoplasmic reti'C- ulum (microsomes), nuclei, and chloroplasts. Oxygen is also acti- vated in biologically relevant photosensitizing reactions to highly re- active singlet oxygen, 10, 2 In all biological systems, 0;- undergoes further reduction to H 0 2 2 via Fenton reaction to the hydroxyl radical, -OH. These, and some other forms of activated O, constitute reactive oxygen species (ROS) 2 and/or metabolites (ROM). Both 'OH and 10 are the most reactive 2 forms of ROS known and among their deleterious reactions are ox- idation of proteins, DNA, steroidal compounds, and peroxidation of the cell membrane's unsaturated lipids to form unstable hydro- peroxides. Their many breakdown products include malondialde- hyde and hydroxynonenals that are themselves highly reactive and threaten cellular integrity and function. More importantly, they de- compose to free radicals that can continue to propagate the vicious lipid peroxidation chain reaction. This is the so-called endogenous oxidative stress with which all aerobic organisms must cope.
Автор: Ronald Thurman Название: Alcohol and Aldehyde Metabolizing Systems-IV ISBN: 1475714211 ISBN-13(EAN): 9781475714210 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Emel Arin?; John B. Schenkman; Ernest Hodgson Название: Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes ISBN: 146137202X ISBN-13(EAN): 9781461372028 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997
Описание: Proceedings of the NATO Advances Study Institute on Molecular Mechanisms of Transcellular Signalling: from the Membrane to the Gene, held at the Island of Spetses, Greece, August 15-27, 1994
Автор: Jakob Название: Oxidative Stress and Redox Regulation ISBN: 9400757867 ISBN-13(EAN): 9789400757868 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book examines how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.
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