Gene Transfer and Therapy in the Nervous System, Fred H. Gage
Автор: Giacca Mauro Название: Gene Therapy ISBN: 8847016428 ISBN-13(EAN): 9788847016422 Издательство: Springer Рейтинг: Цена: 11738.00 р. 16769.00-30% Наличие на складе: Есть (1 шт.) Описание: Gene Therapy presents a comprehensive overview of the field, ranging from vector development and therapeutic gene selection to the results of the most recent clinical trials. Written in a clear, didactic style, the volume makes gene therapy methods easily accessible to readers.
Описание: The field of gene therapy has undergone remarkable advances, promising to impact human healthcare in the 21st century. This book provides methods for the processing and characterization of viral and non-viral gene transfer vectors, as well as promising approaches to design vectors for efficient, targeted and regulated gene delivery and expression.
Описание: Describes methods for the production of viral and non-viral gene transfer vectors, as well as protocols for critical applications in stem cell biology, cancer, diabetes, HIV and tissue engineering.
Автор: Walter Hendelman, Peter Humphreys and Christopher Название: The Integrated Nervous System ISBN: 1420045970 ISBN-13(EAN): 9781420045970 Издательство: Taylor&Francis Рейтинг: Цена: 10411.00 р. Наличие на складе: Поставка под заказ.
Описание: To demonstrate the connection between academic neuroanatomy and the practice of clinical neurology, this innovative textbook presents carefully chosen clinical cases that illustrate how the nervous system is constructed and how it functions under normal circumstances. Providing the foundation needed to encounter neurological diseases, it teaches students and residents how to integrate a patient?s clinical history and examination with neuroanatomy. In addition to color illustrations throughout, the book adds an invaluable DVD for further exploration and access to a state-of-the-art website with additional materials that are updated periodically.
Описание: * Covers a new approach to gene therapy with a greatly improved safety profile * Complete coverage of the topic including molecular basis, production and biomedical applications * Has a wide audience including everyone who is directly or indirectly involved in the development of gene therapies .
Автор: Merten Название: Viral Vectors for Gene Therapy ISBN: 161779094X ISBN-13(EAN): 9781617790942 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular Biology™ series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.
Автор: Escors Название: Lentiviral Vectors and Gene Therapy ISBN: 3034804016 ISBN-13(EAN): 9783034804011 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.
Автор: Edmund C. Lattime Название: Gene Therapy of Cancer, ISBN: 0123942950 ISBN-13(EAN): 9780123942951 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Поставка под заказ.
Описание: Gene therapy as a treatment for cancer is at a critical point in its evolution. This book offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells.
Автор: James D Clelland Название: Genomics, Proteomics, and the Nervous System ISBN: 1461427797 ISBN-13(EAN): 9781461427797 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses research designed to increase understanding of the nervous system and its structures through the utilization of genomic technologies. It addresses facets including development regulation and changes associated with psychiatric disorders.
Автор: Keith L. March Название: Gene Transfer in the Cardiovascular System ISBN: 1461378818 ISBN-13(EAN): 9781461378815 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient.
Описание: This book seeks to emphasize the importance of molecular technology in the study of neurogenetic mechanisms and to explore the possible relationships between specific cell- cell interactions and regulated gene expression in the develop- ing nervous ~stem.
Автор: Robert C. Griggs; George Karpati Название: Myoblast Transfer Therapy ISBN: 1468458671 ISBN-13(EAN): 9781468458671 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a Muscular Dystrophy Association International Conference held in New York City, June 10--12, 1989
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