Описание: This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions.The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.
Описание: Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. * How do cadherins and catenins interact to assemble AJs and mediate adhesion? * How do AJs interface with other cellular machinery to couple adhesion with the whole cell? * How do AJs affect cell behaviour and multicellular development?
Описание: This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy.
Автор: Escors, David Talmadge, James E. Breckpot, Karine Van Ginderachter, Jo A. Kochan, Grazyna Название: Myeloid-derived suppressor cells and cancer ISBN: 3319268198 ISBN-13(EAN): 9783319268194 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting.
Автор: Michael Andreeff Название: Targeted Therapy of Acute Myeloid Leukemia ISBN: 1493939890 ISBN-13(EAN): 9781493939893 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.
Автор: John G. Monroe; Ellen Rothenberg Название: Molecular Biology of B-Cell and T-Cell Development ISBN: 1617370657 ISBN-13(EAN): 9781617370656 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
Автор: Paul J.R. Barton; Kenneth R. Boheler; Nigel J. Bra Название: Molecular Biology of Cardiac Development and Growth ISBN: 3662221942 ISBN-13(EAN): 9783662221945 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is the only book to specifically combine basic information on molecular biology with current thinking in cardiac development.
Автор: Grace L.C. Shen-Ong; Michael Potter; Neal G. Copel Название: Mechanisms in Myeloid Tumorigenesis 1988 ISBN: 364274625X ISBN-13(EAN): 9783642746253 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Harinder Singh; Rudolf Grosschedl Название: Molecular Analysis of B Lymphocyte Development and Activation ISBN: 3642421881 ISBN-13(EAN): 9783642421884 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation.- Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination.- Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development.- Biochemistry of V(D)J Recombination.- The Pre-B Cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms.- Transcriptional Control of B Cell Activation.-Expression of MHC II Genes.- Class Switch Recombination: An Emerging Mechanism.- Blimp-1, Immunoglobulin Secretion, and the Switch to Plasma Cells.- Wnt Signaling in Lymphopoiesis.- Subject Index
Автор: Cl?vio N?brega; Raquel Rodriguez-L?pez Название: Molecular Mechanisms Underpinning the Development of Obesity ISBN: 3319376292 ISBN-13(EAN): 9783319376295 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Challenges in understanding development of obesity.- Monogenic forms of obesity.- Heterogeneous obesity syndromes: new strategies for diagnosis.- Genetic contribution: common forms of obesity.- The role of the GWAS identified FTO locus in regulating body size and composition.- Neural vulnerability factors that increase risk for weight gain: prevention and treatment implications.- Molecular mechanisms involved in the regulation of food intake.- Epigenetics of human obesity: a link between genetics and nutrition.- MicroRNAs in obesity and metabolism.- Obesity study: animal models.- From Homo obesus to Homo diabesus: neuroadipology insight.- Obesity and type 2 diabetes.
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