Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.
Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.
contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability
documents cutting edge methods
Название: Initiation of dna replication in eukaryotes ISBN: 3319246941 ISBN-13(EAN): 9783319246949 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ГЇВїВЅ Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells.
Автор: Alan Kolber Название: Mechanism and Regulation of DNA Replication ISBN: 1468421263 ISBN-13(EAN): 9781468421262 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Monika Glinkowska; Lidia Boss; Grzegorz Wegrzyn Название: DNA Replication Control in Microbial Cell Factories ISBN: 3319105329 ISBN-13(EAN): 9783319105321 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction.- Coordinating duplication of genetic material with cell growth - current views and old questions.- Structural organization of cellular processes and the regulation of cell cycle.- The link between metabolism and DNA replication.- Transcriptional activation - the unsolved problem.- Activity of DnaA is inhibited by components of translation machinery.- Nucleoid-associated proteins modulate activity of the DnaA initiator.- Interaction of DnaA with acidic components of fluid cellular membrane regulates its nucleotide-bound status and binding to oriC.- Influence of DNA replication on cell structure and function.- Conclusions.
Автор: Huidong Zhang Название: DNA Replication - Damage from Environmental Carcinogens ISBN: 9401772118 ISBN-13(EAN): 9789401772112 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.
Автор: Ulrich Huebscher Название: Proteins Involved in DNA Replication ISBN: 1468487329 ISBN-13(EAN): 9781468487329 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: A. De Recondo Название: New Approaches in Eukaryotic DNA Replication ISBN: 1468443992 ISBN-13(EAN): 9781468443998 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: DNA replication in eukaryotes is an important field, particular- ly because of its direct impact on the study of cancer.
Автор: Patrick Hughes; Ellen Fanning; Masamichi Kohiyama Название: DNA Replication: The Regulatory Mechanisms ISBN: 364276990X ISBN-13(EAN): 9783642769900 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: DNA replication is a key event in the cell cycle. On the other hand, considerableadvances have been made in our understanding of virus DNAreplication and this continues to deepen and broaden ourunderstanding of the controls of cellular DNA replication.
Автор: Craig E. Cameron; Matthias Gotte; Kevin Raney Название: Viral Genome Replication ISBN: 1489984682 ISBN-13(EAN): 9781489984685 Издательство: Springer Рейтинг: Цена: 32651.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process.
