Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling, Ludwig M.G.Jr. Heilmeyer

Автор: Yosef Yarden; Moshe Elkabets
Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
ISBN: 3319679309 ISBN-13(EAN): 9783319679303
Издательство: Springer
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Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.

Автор: Bernhard Kadenbach
Название: Mitochondrial Oxidative Phosphorylation
ISBN: 1493901567 ISBN-13(EAN): 9781493901562
Издательство: Springer
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Описание: This book describes the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation, showing how most of these occur in eukaryotic cells, but not in bacteria or archaea. Coverage includes mitochondrial genes and human disease.

Автор: L.M.G. Jr. Heilmeyer
Название: Cellular Regulation by Protein Phosphorylation
ISBN: 364275144X ISBN-13(EAN): 9783642751448
Издательство: Springer
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Описание: Proceedings of the NATO Advanced Study Institute on Cellular Regulation by Protein Phosphorylation held at Chateau La Londe les Maures (France), September 5-15, 1990

Автор: William R. Bartle; Volker Braun; John M. Dietschy;
Название: Regulation of Plasma Low Density Lipoprotein Levels Biopharmacological Regulation of Protein Phosphorylation Calcium-Activated Neutral Protease Microbial Iron Transport Pharmacokinetic Drug Interactions
ISBN: 3642729045 ISBN-13(EAN): 9783642729041
Издательство: Springer
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Описание: Since it has been demonstrated that reducing the steady-state plasma LDL-cholesterol concentration produces a proportional decrease in the risk of developing atherosclerosis 2), a major effort is now underway to develop safe and effective lipid lowering agents.

Автор: L.M.G. Heilmeyer
Название: Signal Transduction and Protein Phosphorylation
ISBN: 1475701683 ISBN-13(EAN): 9781475701685
Издательство: Springer
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Цена: 6986.00 р.
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Автор: A.M. Municio; M.T. Miras-Portugal
Название: Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease
ISBN: 1461357659 ISBN-13(EAN): 9781461357650
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Описание: Proceedings of a symposium held in El Escorial, Spain, July 5-9, 1993

Автор: R.L. Khandelwal; J.H. Wang
Название: Reversible Protein Phosphorylation in Cell Regulation
ISBN: 1461361133 ISBN-13(EAN): 9781461361138
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Описание: 2 During our formative years with Dr. Krebs at Davis, ed until the ER becomes substantially depleted of Ca +. California, we (c. and M. Brostrom) were imbued with For example, acute exposure of GH3 pituitary cells to 2 2 our continuing interest in the roles of Ca+ and cAMP in Ca+ ionophore A23187 or EGTA has been found to re- biological control mechanisms. We remember our time sult in the inhibition of amino acid incorporation. disap- with Dr. Krebs with great affection both for his intense pearance of polysomal content with accumulation of interest and high standards in science and for his great monosomes and ribosomal subunits. sharp reduction of decency in the treatment of postdoctoral fellows. We the cellular content of 43S pre initiation complex. and have subsequently aspired, within the constraints of our the phosphorylation of elF-2ex and inhibition of eIF-2B ability, to pattern our behavior in accord with this expe- 15-17]. Neither translational elongation nor peptide rience. Our current research involving the control of chain termination appeared to be affected in these ex- protein synthesis at mRNA translation embodies much periments, since average ribosomal transit times and the methionylation of tRNA;met were not altered. Amino of the familiar in protein phosphorylation with some new twists that we shall highlight in this article with our acid incorporation was unaffected during the period of 2 associate. Dr. Prostko. Ca+ release prior to suppression of initiation.

Автор: J. Bell; P. Dunnill; K. Esser; E. Flaschel; M. Hoa
Название: Downstream Processing
ISBN: 3662153289 ISBN-13(EAN): 9783662153284
Издательство: Springer
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Автор: Nikolaos E. Labrou
Название: Protein Downstream Processing
ISBN: 1493960407 ISBN-13(EAN): 9781493960408
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Описание:

Part I. Screening and Design Purification Strategies

1. Protein Purification: An Overview

Nikolaos Labrou

2. Establishment of a Design Space for Biopharmaceutical Purification Processes Using DoE

Ignacio Amadeo, Laura Mauro, Eduardo Ortн, and Guillermina Forno

3. High Throughput Process Development: I. Process Chromatography

A. S. Rathore and R. Bhambure

4. High Throughput Process Development: II. Membrane Chromatography

A. S. Rathore and S. Muthukumar

5. Media Selection in Ion Exchange Chromatography in a Single Microplate

Charlotte Cabanne and Xavier Santarelli

6. High Throughput Screening of Dye-Ligands for Chromatography

Sunil Kumar and Narayan S. Punekar

7. Measurement of Uptake Curves and Adsorption Isotherms by Automated Microscale Chromatography Pipette Tips

Sunil Chhatre and Daniel G. Bracewell

Part II. Low-Resolution Protein Purification Methods

8. Recovery of Recombinant Proteins from Plants Using Aqueous Two-Phase Partitioning Systems: An Outline

Zhengrong GU

9. Aqueous Two-Phase Systems Strategies for the Recovery of Proteins from Plants

Oscar Aguilar and Marco Rito-Palomares

10. Aqueous Two Phase Assisted Precipitation of Proteins: A Platform for Isolation of Process Related Impurities from Therapeutic Proteins

A. S. Rathore and R. Bhambure

11. Simultaneous Purification and Refolding of Proteins by Affinity Precipitation and Macro-(Affinity Ligand) Facilitated Three Phase Partitioning (MLFTPP)

Ipsita Roy, Kalyani Mondal, and Munishwar N. Gupta

12. Co-Expression and Co-Purification of Antigen-Antibody Complexes in Bacterial Cytoplasm and Periplasm

Ario de Marco

13. Immunoglobulin Purification by Caprylic Acid

Victor Morais, Patricia Berasain, and Hugo Massaldi

Part III: High-Resolution Protein Purification Methods

14. Affinity Tags in Protein Purification and Peptide Enrichment: An Overview

Ana Sofia Pina, Нris L. Batalha, and Ana Cecнlia A. Roque

15. Expression and Purification of Large Active GST Fusion Enzymes

Stefania Deceglie, Claudia Lionetti, Marina Roberti, Palmiro Cantatore, and Paola Loguercio Polosa

16. Synthetic Ligand Affinity Chromatography. Purification of Human Serum Albumin and Related Fusion Proteins

Sharon Williams, Phil Morton, and Dev Baines

17. Zbasic - A Purification Tag for Selective Ion-Exchange Recovery

My Hedhammar, Johan Nilvebrant, and Sophia Hober

18. An Orthogonal Fusion Tag for Efficient Protein Purification

Johan Nilvebrant, Mikael Еstrand, and Sophia Hober

19. Phage Display of Engineered Binding Proteins

Mark Levisson, Ruud B. Spruijt, Ingrid Nolla Winkel, Servй W.M. Kengen, and John van der Oost

20. Biomimetic Affinity Ligands for Protein Purification

Isabel T. Sousa and M. Вngela Taipa

21. Synthesis and Application of Dye-Ligand Affinity Adsorbents

Evangelia Chronopoulou and Nikolaos E. Labrou

22. Peptide Affinity Chromatography Based on Combinatorial Strategies for Protein Purification

S. A. Camperi, M. C. Martнnez-Ceron, S. L. Giudicessi, M. M. Marani, F. Albericio, and O. Cascone

23. Affinity Chromatography of Proteins on Monolithic Columns

E.G. Vlakh, G.A. Platonova, and T.B. Tennikova

24. Sample Displacement Batch Chromatography of Proteins

Marta Kotasinska, Verena Richter, Marcel Kwiatkowski, and Hartmut Schlьter

Part IV. Assessing Protein Structural Integrity, Purity, and Stabilization

25. Analysis of Host-Cell Proteins in Biotherapeutic Proteins by LC/MS Approaches

Catalin E. Doneanu, Weibin Chen, an

Автор: Nikolaos E. Labrou
Название: Protein Downstream Processing
ISBN: 1627039767 ISBN-13(EAN): 9781627039765
Издательство: Springer
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Цена: 30745.00 р.
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Описание:

Part I. Screening and Design Purification Strategies

1. Protein Purification: An Overview

Nikolaos Labrou

2. Establishment of a Design Space for Biopharmaceutical Purification Processes Using DoE

Ignacio Amadeo, Laura Mauro, Eduardo Ortн, and Guillermina Forno

3. High Throughput Process Development: I. Process Chromatography

A. S. Rathore and R. Bhambure

4. High Throughput Process Development: II. Membrane Chromatography

A. S. Rathore and S. Muthukumar

5. Media Selection in Ion Exchange Chromatography in a Single Microplate

Charlotte Cabanne and Xavier Santarelli

6. High Throughput Screening of Dye-Ligands for Chromatography

Sunil Kumar and Narayan S. Punekar

7. Measurement of Uptake Curves and Adsorption Isotherms by Automated Microscale Chromatography Pipette Tips

Sunil Chhatre and Daniel G. Bracewell

Part II. Low-Resolution Protein Purification Methods

8. Recovery of Recombinant Proteins from Plants Using Aqueous Two-Phase Partitioning Systems: An Outline

Zhengrong GU

9. Aqueous Two-Phase Systems Strategies for the Recovery of Proteins from Plants

Oscar Aguilar and Marco Rito-Palomares

10. Aqueous Two Phase Assisted Precipitation of Proteins: A Platform for Isolation of Process Related Impurities from Therapeutic Proteins

A. S. Rathore and R. Bhambure

11. Simultaneous Purification and Refolding of Proteins by Affinity Precipitation and Macro-(Affinity Ligand) Facilitated Three Phase Partitioning (MLFTPP)

Ipsita Roy, Kalyani Mondal, and Munishwar N. Gupta

12. Co-Expression and Co-Purification of Antigen-Antibody Complexes in Bacterial Cytoplasm and Periplasm

Ario de Marco

13. Immunoglobulin Purification by Caprylic Acid

Victor Morais, Patricia Berasain, and Hugo Massaldi

Part III: High-Resolution Protein Purification Methods

14. Affinity Tags in Protein Purification and Peptide Enrichment: An Overview

Ana Sofia Pina, Нris L. Batalha, and Ana Cecнlia A. Roque

15. Expression and Purification of Large Active GST Fusion Enzymes

Stefania Deceglie, Claudia Lionetti, Marina Roberti, Palmiro Cantatore, and Paola Loguercio Polosa

16. Synthetic Ligand Affinity Chromatography. Purification of Human Serum Albumin and Related Fusion Proteins

Sharon Williams, Phil Morton, and Dev Baines

17. Zbasic - A Purification Tag for Selective Ion-Exchange Recovery

My Hedhammar, Johan Nilvebrant, and Sophia Hober

18. An Orthogonal Fusion Tag for Efficient Protein Purification

Johan Nilvebrant, Mikael Еstrand, and Sophia Hober

19. Phage Display of Engineered Binding Proteins

Mark Levisson, Ruud B. Spruijt, Ingrid Nolla Winkel, Servй W.M. Kengen, and John van der Oost

20. Biomimetic Affinity Ligands for Protein Purification

Isabel T. Sousa and M. Вngela Taipa

21. Synthesis and Application of Dye-Ligand Affinity Adsorbents

Evangelia Chronopoulou and Nikolaos E. Labrou

22. Peptide Affinity Chromatography Based on Combinatorial Strategies for Protein Purification

S. A. Camperi, M. C. Martнnez-Ceron, S. L. Giudicessi, M. M. Marani, F. Albericio, and O. Cascone

23. Affinity Chromatography of Proteins on Monolithic Columns

E.G. Vlakh, G.A. Platonova, and T.B. Tennikova

24. Sample Displacement Batch Chromatography of Proteins

Marta Kotasinska, Verena Richter, Marcel Kwiatkowski, and Hartmut Schlьter

Part IV. Assessing Protein Structural Integrity, Purity, and Stabilization

25. Analysis of Host-Cell Proteins in Biotherapeutic Proteins by LC/MS Approaches

Catalin E. Doneanu, Weibin Chen, an