The Molecular Biology of Autoimmune Disease, Andrew G. Demaine; J.-Paul Banga; Alan M. McGregor
Автор: Ian R. Mackay Название: The Autoimmune Diseases, ISBN: 0123849292 ISBN-13(EAN): 9780123849298 Издательство: Elsevier Science Рейтинг: Цена: 25791.00 р. Наличие на складе: Поставка под заказ.
Описание: Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors.
Автор: Michael B. A. Oldstone Название: Molecular Mimicry: Infection Inducing Autoimmune Disease ISBN: 3642421830 ISBN-13(EAN): 9783642421839 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular Mimicry, Microbial Infection and Autoimmune Disease: Evolution of the Concept.- A Virus-Induced Molecular Mimicry Model of Multiple Sclerosis.- Suppression of Autoimmunity via Microbial Mimics of Altered Peptide Ligands.- Molecular and Cellular Mechanisms, Pathogenesis and Treatment of Insulin-Dependent Diabetes Obtained Through Study of a Transgenic Model of Molecular Mimicry.- Trypanosoma cruzi-Induced Molecular Mimicry and Chagas' Disease.- HTLV-1-Induced Molecular Mimicry in Neurologic Disease.- Molecular Mimicry: Anti-DNA Antibodies Bind Microbial and Non-Nucleic Acid Self Antigens.- The Structural Interactions Between T-Cell Receptors and MHC/Peptide Complexes Place Physical Limits on Self-Nonself Discrimination.- Subject Index
Описание: Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable Provides a detailed and comprehensive summary of the childhood diseases that are caused by the immune system and their treatments .
Автор: Jorge R. Oksenberg; David Brassat Название: Immunogenetics of Autoimmune Disease ISBN: 1489997482 ISBN-13(EAN): 9781489997487 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches.
Автор: Adams Название: Autoimmune Disease ISBN: 9400769369 ISBN-13(EAN): 9789400769366 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Furthermore, Ebringer`s discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all autoimmune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.
Автор: Jingwu Zhang Название: Immune Regulation and Immunotherapy in Autoimmune Disease ISBN: 1441942092 ISBN-13(EAN): 9781441942098 Издательство: Springer Рейтинг: Цена: 24456.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume reviews the most recent advances in the understanding of cellular and molecular mechanisms for immune responses and immune regulation. The books editor, Dr. Zhang, is well-known internationally, particularly in the field of multiple sclerosis and T-cell vaccination as a potential treatment of multiple sclerosis.
Автор: D.A. Isenberg; S. Spiro Название: Autoimmune Aspects of Lung Disease ISBN: 3034898304 ISBN-13(EAN): 9783034898300 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lung and its contiguous structures are commonly involved in several of the rheumatic diseases (Table 1), either by direct manifestation of disease or as a secondary effect from infection or complications of therapy. In this chapter, we detail the various pulmonary manifestations of the major rheu- matological conditions. The common symptoms of pulmonary diseases and how frequently they are implicated in rheumatic disorders are review- ed. In addition, radiology and physiology of the lung, diagnostic proce- dures and therapeutic options are discussed. Table l. Respiratory associations of the rheumatic disorders Disease Airways Parenchyma Vessels WalVmuscles Lung Pleura Pulmonary Chest pleurisy hypertension Rheumatoid bronchiectasis, pneumonia, arthritis obliterative fibrosing effusion bronchiolitis alveolitis, empyema nodules Systemic pneumonia pleurisy hypertension lupus fibrosing effusion shrinking lungs erythematosus alveolitis, with high atelectasis diaphragm Systemic bronchiectasis fibrosing hypertension "encased chest" sclerosis alveolitis, aspiration pneumonia Sjogren's bronchitis fibrosing alveolitis syndrome lymphoma Dermatomyositis aspiration myopathy polymyositis pneumonia, fibrosing alveolitis Ankylosing upper lobe cos- spondylitis fibrosis vertebral fixation joint Behget's haemorrhage aneurysm syndrome Relapsing upper airway polychondritis narrowing Pulmonary vasculitides nodules The Respiratory System in Rheumatic Diseases 25 1. 2. Respiratory Symptoms The most common respiratory symptoms in patients with rheumatic disease and pulmonary involvement are non-specific and include cough, breathlessness and chest pain and can be the result of involvement of air- ways, lung parenchyma, pleura, chest wall or pulmonary vessels. 1. 3. Tissue Involvement 1. 3. 1.
Автор: Pere Santamaria; Peter Hackett Название: Cytokines and Chemokines in Autoimmune Disease ISBN: 1461349524 ISBN-13(EAN): 9781461349525 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention.
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