Автор: Greg Lever Название: Large-Scale Quantum-Mechanical Enzymology ISBN: 3319369474 ISBN-13(EAN): 9783319369471 Издательство: Springer Рейтинг: Цена: 13059.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This work establishes linear-scaling density-functional theory (DFT) as a powerful tool for understanding enzyme catalysis, one that can complement quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics simulations.
Автор: Price & Stevens Название: Fundamentals of Enzymology. 3ed.IE ISBN: 019850229X ISBN-13(EAN): 9780198502296 Издательство: Oxford Academ Рейтинг: Цена: 11562.00 р. Наличие на складе: Поставка под заказ.
Описание: Enzymes are biological catalysts that have a number of remarkable properties. Fundamentals of Enzymology, 3rd ed builds on the strengths of the previous two editions to show how we can understand these properties and explain how enzymes work in cells and organisms and how they can be clinically and commercially exploited.
Автор: Spies, Maria Название: Methods in Enzymology ISBN: 012809267X ISBN-13(EAN): 9780128092675 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Single-Molecule Enzymology, Part A, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in single-molecule enzymology, and includes sections on such topics as force-based and hybrid approaches, fluorescence, high-throughput sm enzymology, nanopores, and tethered particle motion.
Автор: Jon Lorsch Название: Laboratory Methods in Enzymology: Protein Part D,552 ISBN: 0128002794 ISBN-13(EAN): 9780128002797 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The critically acclaimed laboratory standard for almost 50 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 520 volumes and 40,000 chapters in the collection, much of the material is still relevant today and is truly an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research, and genetics, just to name a few.
In this volume, number 545, we have brought together a number of core protocols concentrating on protein, carefully written and edited by experts.
Автор: Kozo Nakamura; Masuo Aizawa; Osato Miyawaki Название: Electro-enzymology Coenzyme Regeneration ISBN: 3642731260 ISBN-13(EAN): 9783642731266 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Gregory I. Mashanov; Christopher Batters Название: Single Molecule Enzymology ISBN: 149396190X ISBN-13(EAN): 9781493961900 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This an ideal guide for the diverse community of molecular biologists, biochemists, and biophysicists studying enzymes in detail. Experts in the field provide procedures which enable the extraction of detailed information about enzyme work cycles.
Автор: Henry Weiner; Ronald Lindahl; David W. Crabb; T. G Название: Enzymology and Molecular Biology of Carbonyl Metabolism 6 ISBN: 1461376920 ISBN-13(EAN): 9781461376927 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the 8th International Workshop held in Deadwood, South Dakota, June 29-July 3, 1996
Автор: Henry Weiner; David W. Crabb; T. Geoffrey Flynn Название: Enzymology and Molecular Biology of Carbonyl Metabolism 4 ISBN: 1461362598 ISBN-13(EAN): 9781461362593 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Sixth International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism was held outside of Dublin, Ireland at the end of June, 1992. During the past decade site directed mutagenesis to probe for the active site of an enzyme has become part of traditional enzymology;
Автор: Christopher W. Wharton Название: Molecular Enzymology ISBN: 1461585341 ISBN-13(EAN): 9781461585343 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Greg Lever Название: Large-Scale Quantum-Mechanical Enzymology ISBN: 3319193503 ISBN-13(EAN): 9783319193502 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This work establishes linear-scaling density-functional theory (DFT) as a powerful tool for understanding enzyme catalysis, one that can complement quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics simulations. The thesis reviews benchmark studies demonstrating techniques capable of simulating entire enzymes at the ab initio quantum-mechanical level of accuracy. DFT has transformed the physical sciences by allowing researchers to perform parameter-free quantum-mechanical calculations to predict a broad range of physical and chemical properties of materials. In principle, similar methods could be applied to biological problems. However, even the simplest biological systems contain many thousands of atoms and are characterized by extremely complex configuration spaces associated with a vast number of degrees of freedom. The development of linear-scaling density-functional codes makes biological molecules accessible to quantum-mechanical calculation, but has yet to resolve the complexity of the phase space. Furthermore, these calculations on systems containing up to 2,000 atoms can capture contributions to the energy that are not accounted for in QM/MM methods (for which the Nobel prize in Chemistry was awarded in 2013) and the results presented here reveal profound shortcomings in said methods.
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