Описание: This book fills the void to provide a comprehensive review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine.
Автор: Reginald Dean; Edward J. Bilsky; S. Stevens Negus Название: Opiate Receptors and Antagonists ISBN: 1617378224 ISBN-13(EAN): 9781617378225 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders, traumatic injury, pruritis, and movement disorders. These potential treatments involve both novel chemical entities and classic opioid antagonists with improved drug delivery systems. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent the efforts from some of the leading international scientists and clinicians making use of the l- est information emerging from the study of the opioid receptor system. Given the number of researchers currently active in this and related fields of study, it would be inappropriate to suggest that the entire range of activities is fully reflected in this single volume. Instead, a variety of experimental and clinical approaches involving the fields of neuroscience, molecular biology, biochemistry, anatomy, pharmacology, psychology, and psychiatry have been chosen to illustrate rapidly developing experimental and therapeutic areas.
Автор: Edward J. Pavlik Название: Estrogens, Progestins, and Their Antagonists ISBN: 1461286506 ISBN-13(EAN): 9781461286509 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: v. K. Moudgil, Series Editor INTRODUCTION TO VOLUME 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii Edward J Pavlik ABOUT VOLUME 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xvi Edward J Pavlik CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xix Part I: ESTROGEN AND PROGESTIN PHYSIOLOGICAL FuNCTION 1. Pituitary and Brain Actions of Estrogen and Progesterone in the Regulation of Primate Prolactin Secretion. . . . . . . . . . . . . . . . . . . . . . . 3 C. L. Bethea, S. G. Kohama, and M. Pecins-Thompson 2. Saccharomyces cerevisiae As a Model System to Study Steroid Hormone Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " 47 Brandee L. Wagner and Donald P McDonnell 3. Physiological Findings from Transgenic Mouse Models with Altered Levels of Estrogen Receptor Expression. . . . . . . . . . . . . . . . . . . . 69 John F Couse, Vicki L. Davis, and Kenneth S. Korach Part II: MOLECULAR BIOLOGY OF STEROID RECEPTORS AND GENE EXPRESSION 4. New Models and Insights in Steroid Hormone Action . . . . . . . . . . . . . . . . 101 Lisa L. Wei 5. A Role for Progesterone in Multidrug Resistance . . . . . . . . . . . . . . . . . . . . 123 Shyamali Mallick and Susan Band Horwitz 6. Dominant Negative Activity by Estrogen and Progesterone Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 Paul M. Yen 7. Estrogen and Progesterone Receptors in Human Endometrial Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169 Kian Behbakht and Jeff Boyd x Contents Part m: FACTORS ENHANCING RECEPTOR FuNCllON 8. Facilitated Binding of Steroid Hormone Receptors to Target DNA by the Chromatin High-Mobility Group Protein-1: Protein Manipulation of DNA Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 Dean P. Edwards and Paul Prendergast 9. Use of FK506 and Its Analogs in Studying Progesterone Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217 Ping-Kaung Ku Tai and Lee E. Faber KEYWORD INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231 Foreword These two volumes on Estrogens, Progestins, and Their Antagonists repre- sent a thematic extension of the series, Hormones in Health and Disease.
Автор: Winifred G. Nayler Название: Second Generation of Calcium Antagonists ISBN: 3540542159 ISBN-13(EAN): 9783540542155 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Providing an account of recent developments in the field, this study emphasizes the rationale for the development of second-generation calcium antagonists and the advantages associated with their use. It also explains the basis of tissue selectivity exhibited by some of the newer drugs.
Автор: Nicholas Sperelakis; J.B. Caulfield Название: Calcium Antagonists ISBN: 1461338123 ISBN-13(EAN): 9781461338123 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983
Автор: T. Godfraind; S. Govoni; Rodolfo Paoletti; Paul M. Название: Calcium Antagonists ISBN: 9401047561 ISBN-13(EAN): 9789401047562 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Although the importance of calcium (Ca2]) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades. As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally. This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.
Автор: Claudia Trenkwalder; Helmut Lydtin; A. Fleckenstei Название: Calcium Antagonists ISBN: 3642748899 ISBN-13(EAN): 9783642748899 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Dalip J.S. Sirinathsinghji; Ray G. Hill Название: NMDA Antagonists as Potential Analgesic Drugs ISBN: 3034894538 ISBN-13(EAN): 9783034894531 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca- demic and pharmaceutical laboratories to identify novel pain targets and to devel- op novel analgesic drugs. It is clear from numerous studies that the NMDA recep- tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe- cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi- cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol- ume is very timely.
Описание: Demands on a Neurosurgeon Under Routine Clinical Conditions' "Hardly any other field of surgery requires such meticulous asepsis. No other field requires such a protection of the tissue and such reliable hemostasis. No one will question that neurosurgery makes exceedingly high demands. However, the degree of the demands on the personal- ity of the surgeon who has to carry out very serious operations to the exclusion of all others and has little opportuinity to recover psycholog- ically by working on simpler cases is concealed from the outer world. The mental strain which the coworkers and staff have to tolerate may not be denied". So wrote Wilhelm Tonnis in 1939. Although fifty years have now elapsed, his appraisal is still relevant today - hence my intention to discuss the everyday demands placed on neurosurgeons. My aim is not self-glorification to engender sympathy; rather it is to highlight the effects and repercussions of such demands for the well-being of the patients entrusted to us. The major onerous demands include: - those in the operating theater - those resulting from staff problems in nursing - those resulting from legal developments - those resulting from the increasing administrative tasks that cost valuable time and energy which are lost to our actual work in look- ing after patients: science and research also suffer from this. I shall not go into the latter point within this preface. Let me first turn to the strains occurring in the operating theater.
Автор: Nicholas Sperelakis; J.B. Caulfield Название: Calcium Antagonists ISBN: 0898386551 ISBN-13(EAN): 9780898386554 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: B?rje Uvn?s Название: Histamine and Histamine Antagonists ISBN: 3642758428 ISBN-13(EAN): 9783642758423 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
