Описание: This book fills the void to provide a comprehensive review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine.
Автор: Karl-Horst Bichler; Walter L. Strohmaier Название: Nephrocalcinosis Calcium Antagonists and Kidney ISBN: 3642728596 ISBN-13(EAN): 9783642728594 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The effect of calcium antagonists on heart muscle and blood circulation is the reason that they have found widespread clinical application for a number of years. Our understanding of the effect of calcium antagonists is in large part based on the results of morphologic, physiologic, and pharmacologic studies of calcium in the kidneys.
Автор: Mancia Название: Angiotensin Ii Receptor Antagonists ISBN: 1841845795 ISBN-13(EAN): 9781841845791 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Нет в наличии.
Описание: Angiotensin II Receptor Antagonists
Автор: Nicholas Sperelakis; J.B. Caulfield Название: Calcium Antagonists ISBN: 1461338123 ISBN-13(EAN): 9781461338123 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983
Автор: Dalip J.S. Sirinathsinghji; Ray G. Hill Название: NMDA Antagonists as Potential Analgesic Drugs ISBN: 3764360119 ISBN-13(EAN): 9783764360115 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This book gives information on molecular biology, physiology and pharmacology of NMDA receptors.
Автор: Dalip J.S. Sirinathsinghji; Ray G. Hill Название: NMDA Antagonists as Potential Analgesic Drugs ISBN: 3034894538 ISBN-13(EAN): 9783034894531 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca- demic and pharmaceutical laboratories to identify novel pain targets and to devel- op novel analgesic drugs. It is clear from numerous studies that the NMDA recep- tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe- cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi- cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol- ume is very timely.
Автор: Claudia Trenkwalder; Helmut Lydtin; A. Fleckenstei Название: Calcium Antagonists ISBN: 3642748899 ISBN-13(EAN): 9783642748899 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Nandkumar S. Shah; Alexander G. Donald Название: Endorphins and Opiate Antagonists in Psychiatric Research ISBN: 1468411217 ISBN-13(EAN): 9781468411218 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha- nisms mediating the synaptic action, and to the appraisal of the involve- ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.
Автор: T. Godfraind; S. Govoni; Rodolfo Paoletti; Paul M. Название: Calcium Antagonists ISBN: 9401047561 ISBN-13(EAN): 9789401047562 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Although the importance of calcium (Ca2]) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades. As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally. This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.
Автор: B?rje Uvn?s Название: Histamine and Histamine Antagonists ISBN: 3642758428 ISBN-13(EAN): 9783642758423 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Niklaus E. Gyr; Guido Adler; Christoph Beglinger Название: Cholecystokinin Antagonists in Gastroenterology ISBN: 3642763642 ISBN-13(EAN): 9783642763649 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists.
Автор: Nicholas Sperelakis; J.B. Caulfield Название: Calcium Antagonists ISBN: 0898386551 ISBN-13(EAN): 9780898386554 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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