Описание: This book fills the void to provide a comprehensive review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine.
Описание: Held at Boppard, Germany, October 3-6, 1984
Автор: Dalip J.S. Sirinathsinghji; Ray G. Hill Название: NMDA Antagonists as Potential Analgesic Drugs ISBN: 3764360119 ISBN-13(EAN): 9783764360115 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This book gives information on molecular biology, physiology and pharmacology of NMDA receptors.
Автор: Winifred G. Nayler Название: Second Generation of Calcium Antagonists ISBN: 3540542159 ISBN-13(EAN): 9783540542155 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Providing an account of recent developments in the field, this study emphasizes the rationale for the development of second-generation calcium antagonists and the advantages associated with their use. It also explains the basis of tissue selectivity exhibited by some of the newer drugs.
Автор: Claudia Trenkwalder; Helmut Lydtin; A. Fleckenstei Название: Calcium Antagonists ISBN: 3642748899 ISBN-13(EAN): 9783642748899 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: T. Godfraind; S. Govoni; Rodolfo Paoletti; Paul M. Название: Calcium Antagonists ISBN: 9401047561 ISBN-13(EAN): 9789401047562 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Although the importance of calcium (Ca2]) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades. As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally. This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.
Автор: Reginald Dean; Edward J. Bilsky; S. Stevens Negus Название: Opiate Receptors and Antagonists ISBN: 1617378224 ISBN-13(EAN): 9781617378225 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders, traumatic injury, pruritis, and movement disorders. These potential treatments involve both novel chemical entities and classic opioid antagonists with improved drug delivery systems. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent the efforts from some of the leading international scientists and clinicians making use of the l- est information emerging from the study of the opioid receptor system. Given the number of researchers currently active in this and related fields of study, it would be inappropriate to suggest that the entire range of activities is fully reflected in this single volume. Instead, a variety of experimental and clinical approaches involving the fields of neuroscience, molecular biology, biochemistry, anatomy, pharmacology, psychology, and psychiatry have been chosen to illustrate rapidly developing experimental and therapeutic areas.
Автор: Niklaus E. Gyr; Guido Adler; Christoph Beglinger Название: Cholecystokinin Antagonists in Gastroenterology ISBN: 3642763642 ISBN-13(EAN): 9783642763649 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists.
Автор: Eric Ertel; Th?ophile Godfraind Название: Calcium Channel Blockers ISBN: 3034895992 ISBN-13(EAN): 9783034895996 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects. It covers historical development, pharmacology, clinical aspects, and perspectives.
Автор: E. Carafoli; J. Krebs Название: Calcium Homeostasis ISBN: 3642635326 ISBN-13(EAN): 9783642635328 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: When the kidney fails its intended mission to manage the body`s waste products, physicians must perform multi-level and simultaneous adjustments to replicate kidney function. The management of the body`s absorption, reabsorption, utilization and excretion of calcium and phosphate requires constant fine tuning.
Автор: Gerald Werner Zamponi Название: Voltage-Gated Calcium Channels ISBN: 1441934111 ISBN-13(EAN): 9781441934116 Издательство: Springer Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar- macological targets in the treatment of a variety of disorders, such as epi- lepsy, hypertension, and pain. Voltage-gated calcium channels have there- fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl- edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac- tivity, the book delves into a provocative overview of the history of the cal- cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat- ing, permeation, modulation and interactions with members of the exo- totic machinery--contributed by both established leaders and rising stars in the field.
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