Advances in Nitrate Therapy, Adam Schneeweiss; Marija Weiss

Автор: M. Kaltenbach; G. Kober
Название: Nitrates and Nitrate Tolerance in Angina Pectoris
ISBN: 3642853250 ISBN-13(EAN): 9783642853258
Издательство: Springer
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Описание: Although nitroglycerin is one of the oldest drugs in cardiology the problem of tolerance is a scientific challenge of today. The proceedings of this symposium highlight the most re- cent questions related to this topic. Apparently, partial tolerance, or rather partial decrease in sensitivity, can arise during nitrate therapy. Probably this is the consequence of a partial readjustment of the vascular system. This readjustment refers particularly to the arterial system, i.e., to the hypoten- sive effect of nitrates in the standing position. A similar effect on the venous side is not present. On the other hand, the results assembled in this volume confirm the experience of many decades that long-term antianginal therapy with nitrates remains effective even when high doses are applied. Thus partial tolerance which also occurs after other vasodilators such as prazosin, does not imply tolerance against antianginal effectiveness. From the information available to- day it is reasonable to treat patients with angina pectoris acutely as well as chronically with nitrates in individually adjusted doses. Frankfurt, November 1982 M. Kaltenbach v Contents Foreword................................................................ V Session 1-Pharmacology Tolerance from the Pharmacokinetic and Pharmacodynamic Viewpoints N. Rietbrock, A. Lassmann, B. G. Woodcock ................................ 3 Does Tolerance Develop During Long-Acting Nitrate Therapy? A Critical Review J. Abrams ............................................................... 13 Pharmacokinetics of Isosorbide Dinitrate During Tolerance Development Ho-Leung Fung .......................................................... 25 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 . . . . . . . . . . . . . . . . . . . Session II - Hemodynamics Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure Joseph A. Franciosa ...................................................... 35 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . . .

Автор: Udho Thadani; Lionel H. Opie
Название: Nitrates Updated
ISBN: 0792334663 ISBN-13(EAN): 9780792334668
Издательство: Springer
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Описание: This review of current research in the use of nitrates as cardiovascular drugs covers such topics as: mechanisms of action of nitrates; short and long-acting oral nitrates for stable angina pectoris; nitrates in myocardial infarction; and nitrates in congestive heart failure.

Автор: Nikhil C. Munshi; Kenneth C. Anderson
Название: Advances in Biology and Therapy of Multiple Myeloma
ISBN: 1489989145 ISBN-13(EAN): 9781489989147
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

Автор: Huss Ralf, Guenther Christine, Hauser Andrea
Название: Advances in Pharmaceutical Cell Therapy
ISBN: 9814616788 ISBN-13(EAN): 9789814616782
Издательство: World Scientific Publishing
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Описание: This textbook is a comprehensive overview of the emerging field of cell-based biopharmaceuticals starting from the underlying biology of stem cell and cell-based products all the way to the initiation of a pivotal clinical trial and the potential business model behind it.

Автор: P. Lichtlen; H.-J. Engel; A. Schrey; H.J.C. Swan
Название: Nitrates III
ISBN: 3642680879 ISBN-13(EAN): 9783642680878
Издательство: Springer
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Описание: Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined.

Автор: Nikhil C. Munshi; Kenneth C. Anderson
Название: Advances in Biology and Therapy of Multiple Myeloma
ISBN: 1489989994 ISBN-13(EAN): 9781489989994
Издательство: Springer
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Описание: Multiple myeloma remains incurable, immune to developments in cancer treatment such as high-dose chemotherapy and new kinds of agents. This volume assesses new approaches currently being developed that overcome drug resistance and improve patient outcomes.

Автор: J. Chrubasik; M. Cousins; E. Martin
Название: Advances in Pain Therapy I
ISBN: 3540555366 ISBN-13(EAN): 9783540555360
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Since 1961, when pain therapy was introduced by Bonica, the-re have been world-wide efforts to establish basic regimensfor the treatment of chronic pain. Yet many patients stillcontinue to suffer from intractable pain despite the availa-bility of effective treatment that would greatly improvetheir quality of life.