The Cytochemical Bioassay of Polypeptide Hormones, J. Chayen
Автор: J. C. Brown Название: Gastric Inhibitory Polypeptide ISBN: 3642817734 ISBN-13(EAN): 9783642817731 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Dr. Raymond Pederson, Dr. Jill Dryburgh and I commenced work on GIP in 1968, when, with the generous help of Professor Viktor Mutt and Professor Erik Jorpes of the Karolinska Inst,itute, Stockholm, we were able to establish that there existed an inhibitory material for acid secretion in cholecystokinin-pancreozymin prepara- tions.
This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.
Автор: Luck Martin Название: Hormones: A Very Short Introduction ISBN: 0199672873 ISBN-13(EAN): 9780199672875 Издательство: Oxford Education Рейтинг: Цена: от 1138.00 р. Наличие на складе: Есть
Описание: Hormones are vital to the workings of the body, and while many people are aware of what hormones do, few have an appreciation of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work.
Автор: Koreaki Ito Название: Regulatory Nascent Polypeptides ISBN: 4431550518 ISBN-13(EAN): 9784431550518 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.
Описание: Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.
Автор: Kenneth McKerns Название: Regulation of Gene Expression by Hormones ISBN: 1468444204 ISBN-13(EAN): 9781468444209 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Among our interests are global resource management, human reproduction, hormonal regulation of normal and cancer cells, study of aging and degenerative diseases, brain peptides, peptide neurotransmitter compounds, mechanism of action of hormones, peptide hormone synthesis, and recombinant DNA techniques.
Автор: Bert O`Malley Название: Receptors for Reproductive Hormones ISBN: 1468432397 ISBN-13(EAN): 9781468432398 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: We are especially grateful to Dr. Philip Corfman and his colleagues of the Population and Reproduction Grants Branch of NICHD for making this Conference possible.
Автор: Hubert Vaudry; Akira Arimura Название: Pituitary Adenylate Cyclase-Activating Polypeptide ISBN: 1461349834 ISBN-13(EAN): 9781461349839 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aptly named `Television`s First Lady` by Walter Ames of the Los Angeles Times, actress Beverly Garland (1926-2008) is also regarded as a Western and science-fiction film icon. In addition to more than 700 TV appearances, she made more than 55 feature and made-for-television films. This comprehensive biography includes a foreword and afterword by her colleagues Joseph Campanella and Peggy Webber.
Автор: Reglodi Название: Pituitary Adenylate Cyclase Activating Polypeptide — PACAP ISBN: 3319351338 ISBN-13(EAN): 9783319351339 Издательство: Springer Рейтинг: Цена: 32652.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first comprehensive book to cover all aspects of the last 25 years of PACAP (pituitary adenylate cyclase activating polypeptide) research, this book contains contributions from virtually all the leading researchers in the field, and addresses some of the following topics: evolutionary aspects of PACAP, distribution and occurrence of PACAP and its receptors, hormonal effects of PACAP, intracellular signaling, effects on cellular proliferation and differentiation, protective effects of PACAP, behavioral effects of PACAP, developmental aspects of PACAP, other physiological effects of PACAP (cardiovascular, thermoregulatory), human studies, drug design, metabolism and transport. This compendium can serve as an important reference for researchers and students in PACAP research and can also be a thorough introduction for those in related fields.
Автор: Alexander V. Yakubovich Название: Theory of Phase Transitions in Polypeptides and Proteins ISBN: 3642269532 ISBN-13(EAN): 9783642269530 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thesis provides novel insights into protein folding by considering the problem from the point of view of statistical mechanics. It presents the first physically motivated quantitative description of the protein folding/unfolding transition.
Автор: Nathan Back Название: Pharmacology of Hormonal Polypeptides and Proteins ISBN: 1489927263 ISBN-13(EAN): 9781489927262 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It can be concluded (under the specific experimental procedures em- ployed) that:- 1) HCG labelled with 1 - 2 atoms of radioactive iodine did not differ sig- nificantly from the unlabelled hormone; 4) When the HCG present in the circulation is bound to an antiserum to HCG, the antigen-antibody complex is not concentrated by the ovary;
Автор: P. Katsoyannis Название: The Chemistry of Polypeptides ISBN: 1461345731 ISBN-13(EAN): 9781461345732 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leonidas Zervas, Emeritus Professor of organic chemistry at the University of Athens, and past president of the National Academy of Greece, cele- brated his seventieth birthday this past year.
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