Oxidative Stress and Vascular Disease, John F. Keaney Jr.
Автор: Armstrong Donald Название: Oxidative Stress Biomarkers and Antioxidant Protocols ISBN: 0896038505 ISBN-13(EAN): 9780896038509 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.
Автор: Smeitink Название: Oxidative Phosphorylation in Health and Disease ISBN: 0306482320 ISBN-13(EAN): 9780306482328 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Includes information on the normal structure, function, and molecular biology of the mitochondrial respiratory chain, traditional diagnostical methodologies. This work features reviews of symptoms and signs associated with syndromes, as well as updates on the genetic defects of either the mitochondrial or the nuclear genome.
Автор: K. Okita Название: HCV/Oxidative Stress and Liver Disease ISBN: 4431670076 ISBN-13(EAN): 9784431670070 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume containing the proceedings of the 13th Yamaguchi Symposium on Liver Disease includes discussion of the direct cellular effects of hepatitis C virus (HCV) proteins on hepatocytes and reviews evidence that oxidative stress caused primarily by the HCV core protein plays a key role in disease pathogenesis.
Автор: K. Okita Название: HCV/Oxidative Stress and Liver Disease ISBN: 4431703241 ISBN-13(EAN): 9784431703242 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume containing the proceedings of the 13th Yamaguchi Symposium on Liver Disease includes discussion of the direct cellular effects of hepatitis C virus (HCV) proteins on hepatocytes and reviews evidence that oxidative stress caused primarily by the HCV core protein plays a key role in disease pathogenesis.
Автор: Smeitink Название: Oxidative Phosphorylation in Health and Disease ISBN: 1441934359 ISBN-13(EAN): 9781441934352 Издательство: Springer Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: CONTENTS Foreword 1.The Human OXPHOS System: Structure, Function and Physiology; Immo E.Scheffler.- Complexes of the Electron Transport Chain.- The ATP Synthase.- Regulation of Oxidative Phosphorylation.- Assembly of Electron Transport Complexes.- 2.Molecular Biology of the OXPHOS System; Richard C.S carpulla.- mtDNA.- Mitochondrial Inheritance.- Replication, Transcription, RNA Processing.- Recombination and Repair.- Mitochondrial Translation System.- Bi-Genomic Expression of the Respiratory Chain.- 3.Clinical Diagnosis of Oxidative Phosphorylation Disorders; Robert McFarland, Patrick F.Chinnery, Robert W.Taylor, Andrew M.Schaefer and Douglass M.Turnbull.- Epidemiology of Defects of Mitochondrial Oxidation.- Clinical Features of Patients with Defects of Mitochondrial Oxidation.- Investigation of Suspected Mitochondrial Disease.- 4.Contribution of Histopathological Examination to the Diagnosis of OXPHOS Disorders; Martin Lammens and Henk ter Laak.- Muscle Biopsy Diagnosis.- Morphological Hallmarks for Diagnosis of OXPHOS Disorders.- Mitochondrial Changes in Muscle Biopsies without OXPHOS Disorder.- Muscle Biopsy in OXPHOS Disorders.- Pathological Findings in Other Organs.- 5.Biochemical Diagnosis of OXPHOS Disorders; J.M.Frans Trijbels, Antoon J.M Janssen, Lambert P.van den Heuvel, Rob C.A.Sengers and Jan A.M.Smeitink.- Examination of Body Fluids.- Examination of Tissues.- Biochemical Diagnostic Investigations.- Frozen Muscle Samples.- Complex IV (Cytochrome c Oxidase).- Complex V.- Practical Guidelines for Biochemical Examinations of Muscle.- Investigation of Fibroblasts.- Residual Enzyme Activity.- 6.Mitochondrial DNA and OXPHOS Disorders; Massimo Zeviani and Valerio Carelli.- General Background.- Mitochondrial Genetics.- Sequence and Gene Organization of mtDNA.- Mitochondrial Disorders Due to Mutations of mtDNA.- Mutations of mtDNA.- Large-Scale Rearrangements.- Point Mutations.- Heteroplasmic Point Mutations.- Other Syndromes.- Homoplasmic mtDNAMutations.- Other Homoplasmic Mutations.- Genetic Counseling.- 7.Nuclear DNA and Oxidative Phosphorylation; Lambert P.van den Heuvel and Jan A.M.Smeitink.- Biochemistry and Molecular Biology of the OXPHOS System.- Nuclear DNA Mutations.- 8.Cell Biological Consequences of OXPHOS Disorders; Werner J.H.Koopman, Henk-Jan Visch, Sjoerd Verkaart and Peter H.G.M.Willems.- Mitochondrial Function in the Living Cell.- Cellular Calcium Signalling.- Cellular Consequences of OXPHOS Deficiency.- 9.Animal Models of OXPHOS Disorders; Nicole Hance and Nils-Gцran Larsson.- A Drosophila Model of Mitochondrial Deafness.- Mouse Models of Nuclear DNA Mutations.- Manipulation of Mitochondrial Transcription Factor A Expression in Mice.- Transmitochondrial Mouse Models.- Defective Nuclear-Mitochondrial DNA Interactions Resulting in Hearing Loss.- 10.Therapeutic Options in OXPHOS Disorders; Rob C.A.Sengers, J.M.Frans Trijbels, Carolien C.A.Boelen, Eva Morava and Jan A.M.Smeitink.- Therapeutic Approaches.- Practical Approaches.- Future Therapies.- Evaluation of Treatment.- 11.Prenatal Diagnostics in Oxidative Phosphorylation Disorders; Antoon J.M.Janssen, Letitia E.M.Niers, Lambert P.van den Heuvel, Jan A.M.Smeitink, Rob C.A.Sengers and J.M.Frans Trijbels.- Prerequisites for Offering Prenatal Diagnosis in OXPHOS Disorders.- Tissues to Be Used for Prenatal Diagnosis in OXPHOS Disorders.- Methods for Prenatal Diagnosis in OXPHOS Disorders.- Results of Prenatal Diagnosis for OXPHOS Disorders in Our Center.- General Considerations.- 12.Future Developments in the Laboratory Diagnosis of OXPHOS Disorders; David R.Thorburn.- In Vivo Assessment of OXPHOS Function.- Minimally Invasive Tissue Samples.- OXPHOS Function.- OXPHOS Constituents.- OXPHOS Genetics.- Prenatal Diagnosis &Prevention.-Index.
Описание: This book discusses oxidative stress and hormesis from the perspective of an evolutionary ecologist or physiologist. The author illustrates how oxidative stress and hormesis have shaped diversity in organism life-histories, behavioral profiles, morphological phenotypes, and aging mechanisms.
Автор: Donald Armstrong Название: Advanced Protocols in Oxidative Stress III ISBN: 1493914405 ISBN-13(EAN): 9781493914401 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Advanced Protocols in Oxidative Stress III continues the thread of the first two books by covering technology ranging from a portable hand-held detector for remote analysis of antioxidant capacity to sophisticated technology such as shotgun lipidomics, mitochondrial imaging, nano sensors, fluorescent probes, chromatographic fingerprints, computational models and bio statistical applications. Several chapters have shown the effect of pro-oxidation and antioxidants as inflammatory mediators in signaling pathways leading from the initial stimulus to termination through redox cycles. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Advanced Protocols in Oxidative Stress III offers to save investigators significant time and effort, allowing them to focus on their own personal topic of interest.
Описание: This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems. Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species.
Автор: Dziubla, Thomas Название: Oxidative Stress and Biomaterials ISBN: 0128032693 ISBN-13(EAN): 9780128032695 Издательство: Elsevier Science Рейтинг: Цена: 22738.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation.
No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations.
In this embattled terrain, the most we can hope for from the biomaterials we design is a type of "meso-compatibility," a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction.
Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death
Brings together the two fields of biomaterials and the biology of oxidative stress
Provides approaches for the design of biomaterials with improved biocompatibility
Описание: Proceedings of the NATO Advances Study Institute on Molecular Mechanisms of Transcellular Signalling: from the Membrane to the Gene, held at the Island of Spetses, Greece, August 15-27, 1994
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