Автор: P. D. Kebabian; M. D. Nathanson Название: Cyclic Nucleotides ISBN: 3642683959 ISBN-13(EAN): 9783642683954 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Alexei V. Tulin Название: Poly(ADP-Ribose) Polymerase ISBN: 1493969927 ISBN-13(EAN): 9781493969920 Издательство: Springer Рейтинг: Цена: 17468.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Detection and Quantification of pADPr
1. Quantitation of Poly(ADP-ribose) by Isotope Dilution Mass Spectrometry
Tabea Zubel, Rita Martello, Alexander Bьrkle, and Aswin Mangerich
2. Quantification of PARP Activity in Human Tissues: Ex Vivo Assays in Blood Cells and Immunohistochemistry in Human Biopsies
Eszter M. Horvath, Zsuzsanna K. Zsengellйr, and Csaba Szabo
3. Detecting and Quantifying pADPr In Vivo
Yi-Chen Lai, Rajesh K. Aneja, Margaret A. Satchell, and Robert S.B. Clark
4. Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor for Subcellular NAD Pools
Magali R. VanLinden, Marc Niere, Andrey A. Nikiforov, Mathias Ziegler, and Christian Dцlle
5. Cell Cycle Resolved Measurements of Poly(ADP-ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry
Jone Michelena and Matthias Altmeyer
Part II: Identification of Protein Targets
6. Detecting Protein ADP-Ribosylation Using a Clickable Aminooxy Probe
Rory K. Morgan and Michael S. Cohen
7. ADP-Ribosylated Peptide Enrichment and Site Identification: The Phosphodiesterase-Based Method
Casey M. Daniels, Shao-En Ong, and Anthony K.L. Leung
8. Using Clickable NAD+ Analogues to Label Substrate Proteins of PARPs
Lu Zhang and Hening Lin
9. Identification of Protein Substrates of Specific PARP Enzymes Using Analog-Sensitive PARP Mutants and a 'Clickable' NAD+ Analog
Bryan A. Gibson and W. Lee Kraus
10. Identification of ADP-Ribose Acceptor Sites on In Vitro Modified Proteins by Liquid Chromatography - Tandem Mass Spectrometry
Mario Leutert, Vera Bilan, Peter Gehrig, and Michael O. Hottiger
11. Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography -Tandem Mass Spectrometry
Sara C. Larsen, Mario Leutert, Vera Bilan, Rita Martello, Stephanie Jungmichel, Clifford Young, Michael O. Hottiger, and Michael L. Nielsen
Part III: Functional Analysis
12. Poly(ADP-Ribose)-Dependent Chromatin Remodeling in DNA Repair
Thйo Lebeaupin, Rebecca Smith, Sйbastien Huet, and Gyula Timinszky
13. Methods to Assess the Role of Poly(ADP-Ribose) Polymerases in Regulating Mitochondrial Oxidative Function
Edit Mikу, Tьnde Kovбcs, Tamбs Fodor, and Pйter Bai
14. Approaches for Investigating Translational Regulation Controlled by PARP1: Biotin-Based UV-Crosslinking and Luciferase Reporter Assay
Yingbiao Ji
15. Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARP1)
Автор: Myron K. Jacobson; Elaine L. Jacobson Название: ADP-Ribose Transfer Reactions ISBN: 1461585090 ISBN-13(EAN): 9781461585091 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: - Enzymology of ADP-Ribosylation - ADP-Ribosylation and Chromatin Function - Carcinogenesis and Differentiation - NAD Metabolism and Chemotherapy - ADP-Ribosylation and Signal Transduction - Molecular Genetic Approaches to ADP-Ribosylation
Автор: Roland Seifert Название: Non-canonical Cyclic Nucleotides ISBN: 3319526715 ISBN-13(EAN): 9783319526713 Издательство: Springer Рейтинг: Цена: 39130.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.
Автор: Alexei V Tulin Название: Poly(ADP-ribose) Polymerase ISBN: 1493962159 ISBN-13(EAN): 9781493962150 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book shows how PARP proteins act in normal and pathogenic development of organisms, advances knowledge of developmental pathways regulation, and furthers development of new drugs and methods to target PARP-dependent processes.
Автор: J. A. Nathanson; M.M. Appleman; J. W. Kebabian; M. Название: Cyclic Nucleotides ISBN: 3642681131 ISBN-13(EAN): 9783642681134 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators.
Описание: Calcium metabolism is regulated by three specific hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP also plays an important part in calcium regulation, and its concentration in urine can be taken as a measure of parathyroid function. Methods for quantitative measurement of, e.g. calcium-regulating hormones and vitamin D metabolites as well as of cAMP are absolutely necessary for safe differential diagnosis of diseases of the parathyroid like hypo- and hyperparathyroidism. In this monograph all presently available methods are summarized as to whether they can already be obtained as test kits or are still being tested. Radioimmunoassays for the various peptide fragments such as 53-84, 44-68, 28-48, and 1-34 are described, as are immunochemiluminescence methods and adenylate cyclase bioassays. The same is true for the vitamin D metabolites, where the various assays for calcidiol and calcitriol such as HPLC, protein-binding assay with second antibody separation, and double antibody RIA are de scribed. Finally, determination of calcitonin and cAMP is discussed in detail. This is a practically and clinically oriented monograph for working in the fields of internal medicine, endocrinology, and laboratory medicine.
Автор: Thomas Krieg; Robert Lukowski Название: Guanylate Cyclase and Cyclic GMP ISBN: 1627034587 ISBN-13(EAN): 9781627034586 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book offers methods to identify elements of the NO/cGMP/PKG pathway and to characterise function, signaling, localisation and importance on a cellular level and in whole animal models. Includes trouble-shooting tips and more.
Автор: Friedrich Koch-Nolte Название: Endogenous ADP-Ribosylation ISBN: 3319345974 ISBN-13(EAN): 9783319345970 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Evolution and Detection of Endogenous ADP-Ribosylation
The natural history of ADP-ribosyltransferases and the ADP ribosylation system
L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer
Identification and Analysis of ADP-ribosylated Proteins
Friedrich Haag and Friedrich Buck
Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)
Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine
Klaus Aktories, Gudula Schmidt and Alexander E. Lang
Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein
Hideaki Tsuge, Toshiharu Tsurumura
Regulation of nitrogenase by reversible mono-ADP-ribosylation
Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo
ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells
Bjцrn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch
Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish
Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe
Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)
Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family
Ana Filipa Pinto and Herwig Schьler
Function and regulation of the mono-ADP-ribosyltransferase ARTD10
Max Kaufmann, Karla L. H. Feijs, and Bernhard Lьscher
Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15
Maria Di Girolamo
Автор: Friedrich Koch-Nolte Название: Endogenous ADP-Ribosylation ISBN: 3319107704 ISBN-13(EAN): 9783319107707 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Evolution and Detection of Endogenous ADP-Ribosylation
The natural history of ADP-ribosyltransferases and the ADP ribosylation system
L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer
Identification and Analysis of ADP-ribosylated Proteins
Friedrich Haag and Friedrich Buck
Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)
Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine
Klaus Aktories, Gudula Schmidt and Alexander E. Lang
Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein
Hideaki Tsuge, Toshiharu Tsurumura
Regulation of nitrogenase by reversible mono-ADP-ribosylation
Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo
ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells
Bjцrn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch
Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish
Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe
Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)
Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family
Ana Filipa Pinto and Herwig Schьler
Function and regulation of the mono-ADP-ribosyltransferase ARTD10
Max Kaufmann, Karla L. H. Feijs, and Bernhard Lьscher
Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15
Maria Di Girolamo
Автор: Friedrich Haag; Friedrich Koch-Nolte Название: ADP-Ribosylation in Animal Tissues ISBN: 1461346525 ISBN-13(EAN): 9781461346524 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of an international workshop held in Hamburg, Germany, May 19-23, 1996
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