Guanylate Cyclase and Cyclic GMP, Thomas Krieg; Robert Lukowski

Автор: J. A. Nathanson; M.M. Appleman; J. W. Kebabian; M.
Название: Cyclic Nucleotides
ISBN: 3642681131 ISBN-13(EAN): 9783642681134
Издательство: Springer
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Цена: 18167.00 р.
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Описание: The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators.

Автор: Hon Cheung Lee
Название: Cyclic ADP-Ribose and NAADP
ISBN: 1461349966 ISBN-13(EAN): 9781461349969
Издательство: Springer
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Цена: 20962.00 р.
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Описание: In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers.

Автор: Heinrich Schmidt-Gayk; Franz P. Armbruster; Roger
Название: Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP Assays and Their Clinical Application
ISBN: 3662004089 ISBN-13(EAN): 9783662004081
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Calcium metabolism is regulated by three specific hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP also plays an important part in calcium regulation, and its concentration in urine can be taken as a measure of parathyroid function. Methods for quantitative measurement of, e.g. calcium-regulating hormones and vitamin D metabolites as well as of cAMP are absolutely necessary for safe differential diagnosis of diseases of the parathyroid like hypo- and hyperparathyroidism. In this monograph all presently available methods are summarized as to whether they can already be obtained as test kits or are still being tested. Radioimmunoassays for the various peptide fragments such as 53-84, 44-68, 28-48, and 1-34 are described, as are immunochemiluminescence methods and adenylate cyclase bioassays. The same is true for the vitamin D metabolites, where the various assays for calcidiol and calcitriol such as HPLC, protein-binding assay with second antibody separation, and double antibody RIA are de scribed. Finally, determination of calcitonin and cAMP is discussed in detail. This is a practically and clinically oriented monograph for working in the fields of internal medicine, endocrinology, and laboratory medicine.

Автор: Roland Seifert
Название: Non-canonical Cyclic Nucleotides
ISBN: 3319526715 ISBN-13(EAN): 9783319526713
Издательство: Springer
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Цена: 39130.00 р.
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Описание: Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.