COX-2 Inhibitors, Michel Pairet; Joanne van Ryn

Автор: Claudiu T. Supuran; Clemente Capasso
Название: Zinc Enzyme Inhibitors
ISBN: 3319461117 ISBN-13(EAN): 9783319461113
Издательство: Springer
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Цена: 30745.00 р.
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Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Автор: Sir John R. Vane; Jack H. Botting; R.M. Botting
Название: Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors
ISBN: 9401090319 ISBN-13(EAN): 9789401090315
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.

Автор: Sir John R. Vane; Jack H. Botting
Название: Selective COX-2 Inhibitors
ISBN: 940106041X ISBN-13(EAN): 9789401060417
Издательство: Springer
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Цена: 13974.00 р.
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Описание: ` The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result- ing from inhibition of the constitutive enzyme.

Автор: Alvaro Macieira-Coelho
Название: Inhibitors of Cell Growth
ISBN: 3642721516 ISBN-13(EAN): 9783642721519
Издательство: Springer
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Цена: 6986.00 р.
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Автор: Timothy D. Warner
Название: Endothelin and Its Inhibitors
ISBN: 3642632378 ISBN-13(EAN): 9783642632372
Издательство: Springer
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Цена: 6986.00 р.
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Описание: With contributions by numerous experts

Автор: Louis M. Aledort; Leon W. Hoyer; Jeanne M. Lusher;
Название: Inhibitors to Coagulation Factors
ISBN: 1461380014 ISBN-13(EAN): 9781461380016
Издательство: Springer
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Цена: 12157.00 р.
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Описание: Proceedings of the Second International Symposium held in Chapel Hill, North Carolina, November 3-5, 1993

Автор: M. Endo; Y. Kurachi; M. Mishina
Название: Pharmacology of Ionic Channel Function: Activators and Inhibitors
ISBN: 3540661271 ISBN-13(EAN): 9783540661276
Издательство: Springer
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Цена: 78366.00 р.
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Описание: With contributions by numerous experts

Автор: Alexey Larionov
Название: Resistance to Aromatase Inhibitors in Breast Cancer
ISBN: 3319382845 ISBN-13(EAN): 9783319382845
Издательство: Springer
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Цена: 18284.00 р.
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Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance.

Автор: Nicola J. Curtin; Ricky A. Sharma
Название: PARP Inhibitors for Cancer Therapy
ISBN: 3319141503 ISBN-13(EAN): 9783319141503
Издательство: Springer
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Цена: 23757.00 р.
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.

Автор: Lorenzo A. Pinna; Patricia T.W. Cohen
Название: Inhibitors of Protein Kinases and Protein Phosphates
ISBN: 3642422063 ISBN-13(EAN): 9783642422065
Издательство: Springer
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Цена: 69876.00 р.
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Описание: The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles.

Автор: Satya Prakash Gupta
Название: Ion Channels and Their Inhibitors
ISBN: 364244282X ISBN-13(EAN): 9783642442827
Издательство: Springer
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Цена: 15672.00 р.
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Описание: The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors.

Автор: Alexey Larionov
Название: Resistance to Aromatase Inhibitors in Breast Cancer
ISBN: 3319179713 ISBN-13(EAN): 9783319179711
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.