Описание: Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from “prealbumin” to “thyroxine-binding prealbumin” to “transthyretin” as knowledge increased about its functions. TTR is synthesised in a wide range of tissues in humans and other eutherian mammals: the liver, choroid plexus (blood- cerebrospinal ?uid barrier), retinal pigment epithelium of the eye, pancreas, intestine and meninges. However, its sites of synthesis are more restricted in other vertebrates. This implies that the number of tissues synthesising TTR during vertebrate evolution has increased, and raises questions about the selection pressures governing TTR synthesis. TTR is most widely known as a distributor of thyroid hormones. In addition, TTR binds retinol-binding protein, which binds retinol. In this way, TTR is also involved with retinoid distribution. More recently, TTR has been demonstrated to bind a wide variety of endocrine disruptors including drugs, pollutants, industrial compounds, heavy metals, and some naturally occurring plant ?avonoids. These not only interfere with thyroid hormone delivery in the body, but also transport such endocrine disruptors into the brain, where they have the potential to accumulate.
Описание: This evolution is evident considering the numerous cell functions performed by plasma membrane redox systems not only in healthy cells but also in cells that escaped from the normal metabolic control (e.g.
Описание: There is a strong interest in transthyretin in connection with protein evolution, medical and clinical research. Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. This monograph presents various developments and discoveries.
Автор: Tomasz Puzyn; Jerzy Leszczynski; Mark T. Cronin Название: Recent Advances in QSAR Studies ISBN: 9400730918 ISBN-13(EAN): 9789400730915 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part consists of a comprehensive review of QSAR methodology. The second part highlights the interdisciplinary aspects and new areas of QSAR modelling.
Описание: Deals with breakthroughs in ion-channel research that have been brought about by joint efforts of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these designed biomolecules. This book is aimed at researchers in nanodevices and biosensors, undergraduate and graduate students in biology.
Автор: Shin-Ho Chung; Olaf S. Anderson; Vikram V. Krishna Название: Biological Membrane Ion Channels ISBN: 1441922075 ISBN-13(EAN): 9781441922076 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Key Features
Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels
Uses schematic diagrams to illustrate important concepts in biophysics
Written by leading researchers in the area of ion channel investigations
Описание: The problem of electron transfer phosphorylation was first formu- lated in 1939 by Belitser and Tsibakova I who introduced the "P: 0" criterion and showed that this ratio is more than 1.
Автор: Herwig J. Hilderson Название: Fluorescence Studies on Biological Membranes ISBN: 1461393612 ISBN-13(EAN): 9781461393610 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Therefore, we have brought together an international group of experts in order to report on and review advances in fluorescence studies on biological membranes, thereby highlighting subcellular aspects. Subsequent chapters dis- cuss more specific applications in cells, biological membranes, and their con- stituents (lipids, proteins).
Описание: Scientific advances over the past two decades have afforded unprecedented oppor- tunities to understand the structure and function of receptors, receptor-ligand interactions, and receptor signaling.
Автор: A. Cato; H. Schaecke; K. Asadullah Название: Recent Advances in Glucocorticoid Receptor Action ISBN: 3662046628 ISBN-13(EAN): 9783662046623 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Название: Recent advances in the analysis of marine toxins ISBN: 0444639411 ISBN-13(EAN): 9780444639417 Издательство: Elsevier Science Рейтинг: Цена: 33518.00 р. Наличие на складе: Поставка под заказ.
Описание:
Recent Advances in the Analysis of Marine Toxins, Volume 78, the newest release in the Comprehensive Analytical Chemistry series, presents chapters from the best authors in the field, making it an essential resource. Updated sections in this new volume include topics such as The importance of toxin detection and quantification: environmental issues, public health, food safety, animal health, bioterrorism, bioactive compounds, medical approach, an LC-MS/MS analysis of marine toxins, Animal bioassays: identification of toxins and mechanism of action, Receptor binding assays for the analysis of marine toxins, Immunoassays and optical biosensors (visual, SPR, fluorescence) for marine toxins, and Electrochemical biosensors for marine toxins.
Chapters in this ongoing series contain practical and useful information, describing real advantages and limitations. Experts in this field contribute based on their research and personal point-of-view.
Автор: Robert K. Poole Название: Recent Advances in Microbial Oxygen-Binding Proteins,67 ISBN: 0128032987 ISBN-13(EAN): 9780128032985 Издательство: Elsevier Science Рейтинг: Цена: 20886.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This latest volume in Advances in Microbial Physiology continues the long tradition of topical and important reviews in microbiology. Contains contributions from leading authorities in the field of microbial physiology Informs and updates on all the latest developments in the field
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