Enzyme Engineering, James C. Samuelson

Автор: Claudiu T. Supuran; Clemente Capasso
Название: Zinc Enzyme Inhibitors
ISBN: 3319461117 ISBN-13(EAN): 9783319461113
Издательство: Springer
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Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Автор: Maddela
Название: Soil Enzymes. Influence of Sugar Industry Effluents on Soil Enzyme Activities
ISBN: 3319426540 ISBN-13(EAN): 9783319426549
Издательство: Springer
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Описание: This book addresses issues arising from discharge of effluents from sugar industry on to surrounding land or into a water body such as physicochemical properties of soil, changes in the micro flora, quantification of soil enzyme activities as influenced by effluents. Disposal of effluents without neutralization has become general practice. These effluents are chemically heterogeneous, contain organic and inorganic pollutants including, sugar baggage, molasses, carbonates, bicarbonates. The impact of sugar industry effluents on microbial activities in terrestrial ecosystem is scanty. There is also significant interest in the study of soil enzymes because such effect reflects the potential capacity of a soil to perform certain biological transformation of soil fertility.

Автор: Young Je Yoo; Yan Feng; Yong-Hwan Kim; Camila Flor
Название: Fundamentals of Enzyme Engineering
ISBN: 9402410244 ISBN-13(EAN): 9789402410242
Издательство: Springer
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Автор: Ichiro Chibata; Saburo Fukui; Lemuel B. Jr. Wingar
Название: Enzyme Engineering
ISBN: 1461592925 ISBN-13(EAN): 9781461592921
Издательство: Springer
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Описание: Under these circumstances, the Sixth Enzyme Engineering Confe- rence was held at Kashikojima, Mie Prefecture, Japan from September 20 to 25, 1981, under the joint auspices of the Engineering Foun- dation of New York and the Japanese Society of Enzyme Engineering.

Автор: C. Vijay Kumar
Название: Rational Design of Enzyme-Nanomaterials,571
ISBN: 0128046805 ISBN-13(EAN): 9780128046807
Издательство: Elsevier Science
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Описание:

Rational Design of Enzyme-Nanomaterials, the new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in rational design of enzyme-nanomaterials, and includes sections on such topics as conjugation of enzymes and dextran-aldehyde polymers, improved activity of enzymes bound to titanate nanosheet, nano-layered 'stable-on-the-table' biocatalysts and nanoparticle-based enzyme sensors.

Название: Enzyme kinetics in drug metabolism
ISBN: 1627037578 ISBN-13(EAN): 9781627037570
Издательство: Springer
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: James C. Samuelson
Название: Enzyme Engineering
ISBN: 1493962876 ISBN-13(EAN): 9781493962877
Издательство: Springer
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Описание: This book provides guidance to those wishing to create enzyme variants. It covers such topics as a simple method for generating site-specific mutations within bacterial chromosomes and the engineering of two difference types of rare-cutting endonucleases.

Автор: Daniel L. Purich
Название: Enzyme Kinetics and Mechanism, Part F: Detection and Characteriza
ISBN: 0121822575 ISBN-13(EAN): 9780121822576
Издательство: Elsevier Science
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Описание: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with mo than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Автор: Helmut Sies
Название: Protein Sensors and Reactive Oxygen Species, Part B: Thiol Enzyme
ISBN: 0121822516 ISBN-13(EAN): 9780121822514
Издательство: Elsevier Science
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Описание: This volume of Methods in Enzymology is a companion to Volume 347 and addresses direct sensing of reactive oxygen species and related free radicals by thiol enzymes and proteins.

Автор: Voth, Gregory
Название: Computational Approaches for Studying Enzyme Mechanism,577
ISBN: 012805347X ISBN-13(EAN): 9780128053478
Издательство: Elsevier Science
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Описание:

Computational Approaches for Studying Enzyme Mechanism Part A, is the first of two volumes in the Methods in Enzymology series, focusses on computational approaches for studying enzyme mechanism.

Автор: Voth, Gregory
Название: Computational Approaches for Studying Enzyme Mechanism Part B,578
ISBN: 0128111070 ISBN-13(EAN): 9780128111079
Издательство: Elsevier Science
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Описание:

Computational Approaches for Studying Enzyme Mechanism, Part B is the first of two volumes in the Methods in Enzymology series that focuses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences.

Автор: Dwevedi
Название: Enzyme Immobilization
ISBN: 331941416X ISBN-13(EAN): 9783319414164
Издательство: Springer
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Описание: This book covers the latest developments in enzyme immobilization with its wide applications, such as for industry, agriculture, medicine, and the environment. Topics covered include basics of enzyme immobilization, its implication in therapeutics and disease diagnostics, and its significance in solving environmental problems. This is an ideal book for researchers, graduate and postgraduate students, as well as scientists in industry, agriculture and health sectors. This book is a complete summary of enzyme immobilization and also thoroughly covers all the latest research.