Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer, Stanley P. L. Leong

Автор: Faruque Riffat; Carsten E. Palme; Michael Veness
Название: Non-melanoma Skin Cancer of the Head and Neck
ISBN: 8132234448 ISBN-13(EAN): 9788132234449
Издательство: Springer
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Описание: However, the spectrum of presentations and subsequent management varies widely, ranging from patients with the ubiquitous low-risk mid-face basal cell carcinoma to those diagnosed with relatively uncommon but potentially life-threatening high-risk squamous cell carcinomas (e.g.

Автор: Stanley P. L. Leong; Yuko Kitagawa; Masaki Kitajim
Название: Selective Sentinel Lymphadenectomy for Human Solid Cancer
ISBN: 1489988696 ISBN-13(EAN): 9781489988690
Издательство: Springer
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In human solid cancer, the lymph node (LN) status is the most important prognostic indicator for the clinical outcome of patients. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of this revolutionary approach to define the first draining or SLN to which the cancer may have metastasized. The underlying thesis in solid cancer biology is that metastasis generally starts in an orderly progression, spreading through the lymphatic channels to the SLN in the nearest LN basin. Thus, the logical approach is to harvest that specific SLN for thorough analysis. Because a tumorfree SLN is usually associated with a negative residual LN basin, a negative SLN is an excellent indication that micrometastasis has not occurred in the regional LNs. When the SLN is involved, it is unknown whether or not metastasis is limited only to the SLN or if the disease has spread to the remainder of the nodal basin. For this reason, if a SLN is positive, a complete lymph node dissection is recommended. Therefore, selective sentinel lymphadenectomy (SSL) should be considered as a staging procedure so that patients with negative SLNs (about 80%) may be spared an extensive LN dissection. Malignant melanoma has been proven to be the most ideal tumor model to study the role of SLN. Subsequently, SSL has been applied to breast cancer, colon cancer and other types of solid cancer. The multidisciplinary approach encompassing the surgeon, nuclear medicine physician, and pathologist is the key to such a successful procedure. Such a team can be formed readily with appropriate training. Beyond the technical aspects of harvesting the SLN, the implication of micrometastasis remains to be defined. Because the follow-up of melanoma and breast cancer patients after SSL is crucial, ongoing clinical trials are in progress to determine the biological and clinical significance of SLNs. Although the concept of SLN is viable in other types of cancer, such as gynecological and gastrointestinal, the technical aspects of the procedure need to be perfected and verified. The most exciting possibility of SSL is that it will lead to early diagnosis of micrometastasis in regional LNs. Early diagnosis makes it useful as a clinical staging procedure, and opens up new opportunities to study micrometastasis and its evolution within the SLNs. Examining the multifaceted aspects of micrometastasis, such as differentiation of different clones with respect to the primary tumor, acquisition of adhesion molecules, and host interaction with the microscopic tumor, will shed new light on the biology of early metastasis. New molecular and genetic tools may be used to dissect the mechanisms of lymphatic and hemo togenous routes of metastasis. If such mechanisms can be understood, new therapeutic advances may be developed to prevent the process of micrometastasis. Rather than targeting larger tumor burdens such as Stage IV disease, targeted adjuvant clinical trials can be developed for high risk patients following definit ive surgical resection. SSL is a standard staging procedure for patients with melanoma and is rapidly evolving into a standard procedure for breast cancer as well.

Автор: A. Rossi-Fanelli; R. Cavaliere; B. Mondovi; G. Mor
Название: Selective Heat Sensitivity of Cancer Cells
ISBN: 3642810829 ISBN-13(EAN): 9783642810824
Издательство: Springer
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Описание: Sponsored by the Swiss League against Cancer

Автор: K.R. Harrap; W. Davis; A.H. Calvert
Название: Cancer Chemotherapy and Selective Drug Development
ISBN: 1461338395 ISBN-13(EAN): 9781461338390
Издательство: Springer
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Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)

Автор: K.R. Harrap; W. Davis; A.H. Calvert
Название: Cancer Chemotherapy and Selective Drug Development
ISBN: 089838673X ISBN-13(EAN): 9780898386738
Издательство: Springer
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Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)

Автор: Giuliano Mariani; Gianpiero Manca; Federica Orsini
Название: Atlas of Lymphoscintigraphy and Sentinel Node Mapping
ISBN: 8847039282 ISBN-13(EAN): 9788847039285
Издательство: Springer
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Описание: This richly illustrated book covers lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. Depicts commonly observed patterns and anatomic variants, and covers technical tips.