Описание: The underlying thesis in solid tumor biology is that metastasis in general starts in an orderly progression with lymphatic spread first to the sentinel lymph node (SLN) in the nearest lymph node basin.
Автор: Javier Gavilan Название: Functional and Selective Neck Dissection ISBN: 3131246316 ISBN-13(EAN): 9783131246318 Издательство: Thieme Verlagsgruppe Рейтинг: Цена: 24773.00 р. Наличие на складе: Поставка под заказ.
Описание: With a whole new approach to neck dissection, this superb book examines the differences between surgical techniques and conceptual approaches to neck dissection. It strives to connect the two points of view, beginning with a historical perspective of the procedure from both the American and Latin perspective. The book creates a better understanding of the reasons behind selective neck dissection, starting with an explanation of the fascial compartmentalization of the neck. This is a step-by-step guide to the operative technique of functional and other non-radical neck dissections. A full list of technical hints and pitfalls, along with nearly 200 color photographs and drawings, are included to enhance the learning process. The book is essential for any professional that wants to understand the rationale, indications, and results of the functional approach to the neck, including otolaryngologists, head and neck surgeons, maxillofacial surgeons, plastic surgeons, and general surgeons.
Автор: K.R. Harrap; W. Davis; A.H. Calvert Название: Cancer Chemotherapy and Selective Drug Development ISBN: 089838673X ISBN-13(EAN): 9780898386738 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)
Автор: K.R. Harrap; W. Davis; A.H. Calvert Название: Cancer Chemotherapy and Selective Drug Development ISBN: 1461338395 ISBN-13(EAN): 9781461338390 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the 10th Anniversary Meeting of the Coordinating Committee for Human Tumour Investigations, Brighton, England (24-28 October 1983)
Автор: Dmitry I. Nurminsky Название: Selective Sweep ISBN: 1441934375 ISBN-13(EAN): 9781441934376 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent advances in genomic sequencing provide the background for analysis of polymorphic sites in large chromosomal regions or even in whole genome, thus providing the tool for effective identification of loci that are under strong pressure of positive selection.
Автор: Stanley P. L. Leong; Yuko Kitagawa; Masaki Kitajim Название: Selective Sentinel Lymphadenectomy for Human Solid Cancer ISBN: 1489988696 ISBN-13(EAN): 9781489988690 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
In human solid cancer, the lymph node (LN) status is the most important prognostic indicator for the clinical outcome of patients. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of this revolutionary approach to define the first draining or SLN to which the cancer may have metastasized. The underlying thesis in solid cancer biology is that metastasis generally starts in an orderly progression, spreading through the lymphatic channels to the SLN in the nearest LN basin. Thus, the logical approach is to harvest that specific SLN for thorough analysis. Because a tumorfree SLN is usually associated with a negative residual LN basin, a negative SLN is an excellent indication that micrometastasis has not occurred in the regional LNs. When the SLN is involved, it is unknown whether or not metastasis is limited only to the SLN or if the disease has spread to the remainder of the nodal basin. For this reason, if a SLN is positive, a complete lymph node dissection is recommended. Therefore, selective sentinel lymphadenectomy (SSL) should be considered as a staging procedure so that patients with negative SLNs (about 80%) may be spared an extensive LN dissection. Malignant melanoma has been proven to be the most ideal tumor model to study the role of SLN. Subsequently, SSL has been applied to breast cancer, colon cancer and other types of solid cancer. The multidisciplinary approach encompassing the surgeon, nuclear medicine physician, and pathologist is the key to such a successful procedure. Such a team can be formed readily with appropriate training. Beyond the technical aspects of harvesting the SLN, the implication of micrometastasis remains to be defined. Because the follow-up of melanoma and breast cancer patients after SSL is crucial, ongoing clinical trials are in progress to determine the biological and clinical significance of SLNs. Although the concept of SLN is viable in other types of cancer, such as gynecological and gastrointestinal, the technical aspects of the procedure need to be perfected and verified. The most exciting possibility of SSL is that it will lead to early diagnosis of micrometastasis in regional LNs. Early diagnosis makes it useful as a clinical staging procedure, and opens up new opportunities to study micrometastasis and its evolution within the SLNs. Examining the multifaceted aspects of micrometastasis, such as differentiation of different clones with respect to the primary tumor, acquisition of adhesion molecules, and host interaction with the microscopic tumor, will shed new light on the biology of early metastasis. New molecular and genetic tools may be used to dissect the mechanisms of lymphatic and hemo togenous routes of metastasis. If such mechanisms can be understood, new therapeutic advances may be developed to prevent the process of micrometastasis. Rather than targeting larger tumor burdens such as Stage IV disease, targeted adjuvant clinical trials can be developed for high risk patients following definit ive surgical resection. SSL is a standard staging procedure for patients with melanoma and is rapidly evolving into a standard procedure for breast cancer as well.
Автор: G.E. Adams; A. Breccia; E.M. Fielden; P. Wardman Название: Selective Activation of Drugs by Redox Processes ISBN: 1461366798 ISBN-13(EAN): 9781461366799 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ARW held in Fermo, Italy, August 28-September 1, 1989
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