The Sentinel Node in Surgical Oncology, I. Taylor; Mohammad R.S. Keshtgar; P.C. Barneveld;
Автор: Pambuccian Название: Lymph Node Cytopathology ISBN: 1441969632 ISBN-13(EAN): 9781441969637 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume in the Essentials in Cytopathology book series will focus on the cytopathology of lymph nodes. It will address the topic of fine needle aspiration of lymph nodes and fulfill the need for an easy-to-use and authoritative synopsis of lymph node cytopathology. The book with adopt an algorithmic diagnostic approach, starting from the cytomorphologic pattern of the lymph node aspirate. The focus will be on the appropriate and effective use of ancillary studies (immunohistochemistry, flow cytometry, fluorescence in situ hybridization and molecular techniques) and integration of their results into the final diagnosis. The book will present the cytopathologic features and differential diagnoses for the major cytologic patterns in lymph node fine needle aspiration. The entities typically falling within each of these patterns will be discussed with illustration of the spectrum of cytologic features, differential diagnoses and pitfalls. The book will cover the full spectrum of benign and malignant primary conditions of the lymph nodes, with emphasis on common disorders. Discussion of metastatic conditions will be restricted to those that are relevant to the differential diagnosis of primary lymphoid disorders. This book is designed as an easy to use resource that fits into the lab coat pocket, ideal for portability and quick reference. It is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities encountered in lymph node aspirates. The accompanying text follows an easy to use pattern-based outline. A useful resource for every pathologist, cytopathologist, fellow and trainee.
Автор: Giuliano Mariani; Gianpiero Manca; Federica Orsini Название: Atlas of Lymphoscintigraphy and Sentinel Node Mapping ISBN: 8847039282 ISBN-13(EAN): 9788847039285 Издательство: Springer Рейтинг: Цена: 23751.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This richly illustrated book covers lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. Depicts commonly observed patterns and anatomic variants, and covers technical tips.
Автор: Stanley P. L. Leong; Yuko Kitagawa; Masaki Kitajim Название: Selective Sentinel Lymphadenectomy for Human Solid Cancer ISBN: 1489988696 ISBN-13(EAN): 9781489988690 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
In human solid cancer, the lymph node (LN) status is the most important prognostic indicator for the clinical outcome of patients. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of this revolutionary approach to define the first draining or SLN to which the cancer may have metastasized. The underlying thesis in solid cancer biology is that metastasis generally starts in an orderly progression, spreading through the lymphatic channels to the SLN in the nearest LN basin. Thus, the logical approach is to harvest that specific SLN for thorough analysis. Because a tumorfree SLN is usually associated with a negative residual LN basin, a negative SLN is an excellent indication that micrometastasis has not occurred in the regional LNs. When the SLN is involved, it is unknown whether or not metastasis is limited only to the SLN or if the disease has spread to the remainder of the nodal basin. For this reason, if a SLN is positive, a complete lymph node dissection is recommended. Therefore, selective sentinel lymphadenectomy (SSL) should be considered as a staging procedure so that patients with negative SLNs (about 80%) may be spared an extensive LN dissection. Malignant melanoma has been proven to be the most ideal tumor model to study the role of SLN. Subsequently, SSL has been applied to breast cancer, colon cancer and other types of solid cancer. The multidisciplinary approach encompassing the surgeon, nuclear medicine physician, and pathologist is the key to such a successful procedure. Such a team can be formed readily with appropriate training. Beyond the technical aspects of harvesting the SLN, the implication of micrometastasis remains to be defined. Because the follow-up of melanoma and breast cancer patients after SSL is crucial, ongoing clinical trials are in progress to determine the biological and clinical significance of SLNs. Although the concept of SLN is viable in other types of cancer, such as gynecological and gastrointestinal, the technical aspects of the procedure need to be perfected and verified. The most exciting possibility of SSL is that it will lead to early diagnosis of micrometastasis in regional LNs. Early diagnosis makes it useful as a clinical staging procedure, and opens up new opportunities to study micrometastasis and its evolution within the SLNs. Examining the multifaceted aspects of micrometastasis, such as differentiation of different clones with respect to the primary tumor, acquisition of adhesion molecules, and host interaction with the microscopic tumor, will shed new light on the biology of early metastasis. New molecular and genetic tools may be used to dissect the mechanisms of lymphatic and hemo togenous routes of metastasis. If such mechanisms can be understood, new therapeutic advances may be developed to prevent the process of micrometastasis. Rather than targeting larger tumor burdens such as Stage IV disease, targeted adjuvant clinical trials can be developed for high risk patients following definit ive surgical resection. SSL is a standard staging procedure for patients with melanoma and is rapidly evolving into a standard procedure for breast cancer as well.
Автор: P.M. Schlag; Umberto Veronesi Название: Lymphatic Metastasis and Sentinel Lymphonodectomy ISBN: 3642630707 ISBN-13(EAN): 9783642630705 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in- creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im- prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique.
Описание: The underlying thesis in solid tumor biology is that metastasis in general starts in an orderly progression with lymphatic spread first to the sentinel lymph node (SLN) in the nearest lymph node basin.
Автор: E. Grundmann; C. Belisle; S. B?dewadt-Radzun; E. V Название: Reaction Patterns of the Lymph Node ISBN: 3642755216 ISBN-13(EAN): 9783642755217 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Despite our original intention to publish all the contributions in one book, it became necessary to divide them: Part 1 focuses on the involved nodal compartments, cell types, and functions, while Part 2 describes their reactions in inflammatory, neo- plastic, and immune-deficient diseases.
Автор: E. Grundmann; D.V. Ablashi; J. Audouin; E. Vollmer Название: Reaction Patterns of the Lymph Node ISBN: 3642755240 ISBN-13(EAN): 9783642755248 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The induction of fibronectin in lymph nodes is effected by tumor cells forming a special part of the extracellular matrix. The multifunctional fibronec- tin molecule serves as a mediator between tumor cells and fibroblasts, furthering the formation of tumor stroma.
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