Innovations for Next-Generation Antibody-Drug Conjugates, Damelin Marc

Автор: Gail Lewis Phillips
Название: Antibody-Drug Conjugates and Immunotoxins
ISBN: 1489997008 ISBN-13(EAN): 9781489997005
Издательство: Springer
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Цена: 22201.00 р.
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Описание: This volume collets leading research on antibody-drug conjugates and immunotoxins. It examines all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Автор: Ducry
Название: Antibody-Drug Conjugates
ISBN: 1627035400 ISBN-13(EAN): 9781627035408
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.

Автор: Ulf Grawunder; Stefan Barth
Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
ISBN: 3319468758 ISBN-13(EAN): 9783319468754
Издательство: Springer
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Цена: 20962.00 р.
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Описание:

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Автор: Kenneth A. Foon; Alton C. Morgan
Название: Monoclonal Antibody Therapy of Human Cancer
ISBN: 089838754X ISBN-13(EAN): 9780898387544
Издательство: Springer
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Цена: 27951.00 р.
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Описание: KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym- phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick- ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju- gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu- lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.

Автор: Roland E. Kontermann; Stefan D?bel
Название: Antibody Engineering Volume 2
ISBN: 3642422764 ISBN-13(EAN): 9783642422768
Издательство: Springer
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Цена: 25155.00 р.
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Описание: Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.

Автор: Laurent Ducry
Название: Antibody-Drug Conjugates
ISBN: 1493960261 ISBN-13(EAN): 9781493960262
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.

Автор: Roland E. Kontermann; Stefan D?bel
Название: Antibody Engineering Volume 2
ISBN: 3642011462 ISBN-13(EAN): 9783642011467
Издательство: Springer
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Цена: 32142.00 р.
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Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.

Автор: Roland E. Kontermann; Stefan D?bel
Название: Antibody Engineering Volume 1
ISBN: 3642011438 ISBN-13(EAN): 9783642011436
Издательство: Springer
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Цена: 41925.00 р.
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Описание: This book is a toolbox of well-established basics and many exciting new techniques in antibody engineering, reflecting the latest hands-on work of key laboratories in this fast-moving field. The new edition is expanded to nearly double the number of protocols.

Автор: Kenneth A. Foon; Alton C. Morgan
Название: Monoclonal Antibody Therapy of Human Cancer
ISBN: 1461296420 ISBN-13(EAN): 9781461296423
Издательство: Springer
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Цена: 13974.00 р.
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Автор: Mohamed Al-Rubeai
Название: Antibody Expression and Production
ISBN: 9400736134 ISBN-13(EAN): 9789400736139
Издательство: Springer
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Цена: 28732.00 р.
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Описание: This book covers generation, optimization, characterization, production and applications of antibodies, offering theoretical background and describing methods for expression of antibody in microbial and animal cell cultures and transgenic animals and plants.