Автор: Minjun Chen; Yvonne Will Название: Drug-Induced Liver Toxicity ISBN: 1493992562 ISBN-13(EAN): 9781493992560 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Поставка под заказ.
Описание: This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results.
Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs.
Chapter 30 is open access under a CC BY 4.0 license via link.springer.com.
Автор: Neil Kaplowitz Название: Drug-Induced Liver Disease, ISBN: 0123878179 ISBN-13(EAN): 9780123878175 Издательство: Elsevier Science Рейтинг: Цена: 29139.00 р. Наличие на складе: Поставка под заказ.
Описание: Suitable for clinicians and scientists in academia, the pharmaceutical industry and government settings, this book contains 4 chapters on key topics in the area and provides an extensive review of the developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.
Автор: Benfenati Название: In Silico Methods for Predicting Drug Toxicity ISBN: 1493936077 ISBN-13(EAN): 9781493936076 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume explores in silico methods forpharmaceutical toxicity by combiningthe theoretical advanced research with the practical application of the tools.Beginning with a section covering sophisticated models addressing the bindingto receptors, pharmacokinetics and adsorption, metabolism, distribution, andexcretion, the book continues with chapters delving into models for specifictoxicological and ecotoxicological endpoints, as well as broad views of themain initiatives and new perspectives which will very likely improve our way ofmodelling pharmaceuticals. Written for the highly successful Methods in Molecular Biology series,chapters include the kind of detailed implementation advice that is key forachieving successful research results.Authoritative and practical, In Silico Methods for Predicting DrugToxicity offers the advantage of incorporating data and knowledge fromdifferent fields, such as chemistry, biology, -omics, and pharmacology, toachieve goals in this vital area of research.
Автор: Robert J. Kavlock; George P. Daston Название: Drug Toxicity in Embryonic Development I ISBN: 3642644082 ISBN-13(EAN): 9783642644085 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Robert J. Kavlock; George P. Daston Название: Drug Toxicity in Embryonic Development II ISBN: 3642644090 ISBN-13(EAN): 9783642644092 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: K.W. Bock; Frederick C. Kauffman; B. Burchell; M. Название: Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity ISBN: 3642784313 ISBN-13(EAN): 9783642784316 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology.
Автор: Emilio Benfenati Название: In Silico Methods for Predicting Drug Toxicity ISBN: 1493980939 ISBN-13(EAN): 9781493980932 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. QSAR Methods
Giuseppina Gini
Part I: Modeling a Pharmaceutical in the Human Body
2. In Silico 3D-Modelling of Binding Activities
Stefano Moro, Mattia Sturlese, Antonella Ciancetta, and Matteo Floris
3. Modeling Pharmacokinetics
Frederic Y. Bois and Cйline Brochot
4. Modeling ADMET
Jayeeta Ghosh, Michael S. Lawless, Marvin Waldman, Vijay Gombar, and Robert Fraczkiewicz
Part II: The Applications of In Silico Models for the Different Endpoints
5. In Silico Prediction of Chemically-Induced Mutagenicity: How to Use QSAR Models and Interpret Their Results
Enrico Mombelli, Giuseppa Raitano, and Emilio Benfenati
6. In Silico Methods for Carcinogenicity Assessment
Azadi Golbamaki and Emilio Benfenati
7. VirtualToxLab: Exploring the Toxic Potential of Rejuvenating Substances Found in Traditional Medicines
Martin Smiesko and Angelo Vedani
8. In Silico Model for Developmental Toxicity: How to Use QSAR Models and Interpret Their Results
Marco Marzo, Alessandra Roncaglioni, Sunil Kulkarni, Tara S. Barton-Maclaren, and Emilio Benfenati
9. In Silico Models for Repeated Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs
Fabiola Pizzo and Emilio Benfenati
10. In Silico Models for Acute Systemic Toxicity
Julien Burton, Andrew P. Worth, Ivanka Tsakovska, and Antonia Diukendjieva
11. In Silico Models for Hepatotoxicity
Mark Hewitt and Katarzyna Przybylak
12. In SilicoModels for Ecotoxicity of Pharmaceuticals
Kunal Roy and Supratik Kar
13. Use of Read-Across Tools
Serena Manganelli and Emilio Benfenati
Part III: The Scientific and Society Challenges
14. Adverse Outcome Pathways as Tools to Assess Drug-Induced Toxicity
Mathieu Vinken
15. A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure
Dennie G.A.J. Hebels, Axel Rasche, Ralf Herwig, Gerard J.P. van Westen, Danyel G.J. Jennen, and Jos C.S. Kleinjans
16. In Silico Study of In Vitro GPCR Assays by QSAR Modeling
Описание: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field.
Автор: Ross Cameron; M.J. Phillips; George Feuer; Felix d Название: Drug-Induced Hepatotoxicity ISBN: 3642646573 ISBN-13(EAN): 9783642646577 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With Contributions by numerous contributors
Автор: Hans-Christoph Diener; Marcia Wilkinson Название: Drug-Induced Headache ISBN: 3642733298 ISBN-13(EAN): 9783642733291 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partially effective, or to add one or more drugs to those which the patient is already taking.
Автор: M. Guslandi; P.C. Braga Название: Drug-Induced Injury to the Digestive System ISBN: 8847022223 ISBN-13(EAN): 9788847022225 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Drugs are often associated with adverse effects, and the digestive tract is the most frequent target. This volume collects a number of updated overviews from experts in this area to offer to the reader a single, complete source of information and reference on that subject.
Описание: Pharmacology of Recreational Drugs: The Neurology of How Drugs Work introduces readers to neurobiology and provides detailed mechanistic explanations of how drugs work. After an opening explanation of normal nerve and brain function, the text goes on to explore how various drugs change the way a person feels and sees the world.While exploring topics such as pharmacokinetics and pharmacodynamics, addiction, cognition, opioids, alcohol, cannabis, hallucinogens, and CNS stimulants the book carefully explains connections starting at the minuscule level of a drug binding to a receptor, through to the holistic – the physiological and psychological effects of the drug on the person. Along the way students learn about the way each drug effects neurons, the role of these neurons in the brain, and the neurobiology of the drug experience.Each chapter includes multiple choice and essay questions for each. Suggestions for further reading create opportunities for extended exploration of the topics. Common-sense and approachable in style, yet comprehensive in coverage, Pharmacology of Recreational Drugs is well-suited to courses in biology, neurobiology, and health sciences, as well as those in nursing programs. It is also suitable for the novice, non-science reader and no prerequisite knowledge is required.
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