Описание: This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.
Автор: Martin F. Fromm; Richard B. Kim Название: Drug Transporters ISBN: 3642266452 ISBN-13(EAN): 9783642266454 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Drug Transporters provides an overview of the most important transporter families for drug therapy. Each chapter is dedicated to a different transporter family, discussing tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Автор: Gordon L. Amidon; Wolfgang Sad?e Название: Membrane Transporters as Drug Targets ISBN: 147578631X ISBN-13(EAN): 9781475786316 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
Автор: Nicholls Glynis, Youdim Kuresh, Fox David Название: Drug Transporters: Volume 2: Recent Advances and Emerging Technologies ISBN: 1782628665 ISBN-13(EAN): 9781782628668 Издательство: Royal Society of Chemistry Рейтинг: Цена: 33581.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.
Описание: Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. This two volume set of books comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. The second volume is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in this set of books ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.
Автор: Qing Yan Название: Membrane Transporters in Drug Discovery and Development ISBN: 1493957333 ISBN-13(EAN): 9781493957330 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.
Автор: Michel F. Eichelbaum; Bernard Testa; Andrew Somogy Название: Stereochemical Aspects of Drug Action and Disposition ISBN: 3642625754 ISBN-13(EAN): 9783642625756 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: G.R. Wilkinson; M.D. Rawlins Название: Drug Metabolism and Disposition ISBN: 085200902X ISBN-13(EAN): 9780852009024 Издательство: Springer Рейтинг: Цена: 37594.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Tse Francis Название: Preclinical Drug Disposition ISBN: 0824785002 ISBN-13(EAN): 9780824785000 Издательство: Taylor&Francis Рейтинг: Цена: 33686.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For researchers and students in pharmacology and related fields, explains the standard techniques for investigating the absorption, distribution, metabolism, and excretion of test compounds using laboratory animals. Describes types of experiments, study design, animal preparation and maintenance, do
Автор: Chikako Tanaka; Norman G. Bowery Название: GABA: Receptors, Transporters and Metabolism ISBN: 3034898584 ISBN-13(EAN): 9783034898584 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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