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Rho GTPases, Rivero


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Автор: Rivero
Название:  Rho GTPases
ISBN: 9781493986118
Издательство: Springer
Классификация:

ISBN-10: 1493986112
Обложка/Формат: Hardcover
Страницы: 419
Вес: 0.97 кг.
Дата издания: 2018
Серия: Methods in Molecular Biology
Язык: English
Размер: 254 x 178 x 24
Основная тема: Protein Science
Подзаголовок: Methods and Protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание:

Part I: Computational Modeling and Imaging

1. Computational Modeling of the Dynamics of Spatiotemporal Rho GTPase Signaling: A Systematic Review

Shabnam Khatibi, Karina Islas Rios, and Lan K. Nguyen

2. Uncovering Bistability in the Rac1/RhoA Signaling Network through Integrating Computational Modeling and Experimentation

Alex von Kriegsheim and Lan K. Nguyen

3. Modeling Rho GTPase Dynamics Using Boolean Logic

Joseph H.R. Hetmanski, Jean-Marc Schwartz, and Patrick T. Caswell

4. EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity

Anastasia Zhurikhina, Timothy Qi, Klaus M. Hahn, Timothy C. Elston, and Denis Tsygankov

5. Applying Perturbation Expectation-Maximization to Protein Trajectories of Rho GTPases

Peter K. Koo and Simon G.J. Mochrie

6. Parallel High Resolution Imaging of Leukocyte Chemotaxis under Agarose with Rho Family GTPase Biosensors

George R.R. Bell, Dean E. Natwick, and Sean R. Collins

7. Characterization of Genetically-Encoded FRET Biosensors for Rho Family GTPases

Sara K. Donnelly, Veronika Miskolci, Alice M. Garrastegui, Dianne Cox, and Louis Hodgson

8. Screening for Rho GTPase Modulators in Actin-Dependent Processes Exemplified by Phagocytosis

Daniel Schlam, Sergio Grinstein, and Spencer A. Freeman

Part II: Biochemistry and High Throughput Methods

9. An In Vitro Kinase Assay to Assess Rac1 Phosphorylation by ERK

Daniel Brandwein, Junfeng Tong, Laiji Li, Barbara Ballermann, and Zhixiang Wang

10. Methods to Study Rho GTPases Using Bacterial Toxins

Gudula Schmidt

11. Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione

Hannah Edenbaum and Jingyan Han

12. High Throughput Assay for RhoGEFs Based on the Transcreener(R) GDP Assay

Robert G. Lowery and Meera Kumar

13. Small Volume Flow Cytometry-Based Multiplex Analysis of the Activity of Small GTPases

Peter Simons, Virginie Bondu, Angela Wandinger-Ness, and Tione Buranda

Part III: Cell Types and Processes

14. Methods to Study the Roles of Rho GTPases in Platelet Function

Francisco Rivero and Simon Calaminus

15. Methods to Investigate the Role of Rho GTPases in Osteoclast Function

Anne Morel, Anne Blangy, and Virginie Vives

16. Methods to Study the Role of Cdc42, Rac1 and Rac2 in B Cell Cytoskeletal Respon



Rho GTPases

Автор: Francisco Rivero
Название: Rho GTPases
ISBN: 1493958968 ISBN-13(EAN): 9781493958962
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Rho GTPase: Methods and Protocols provides a historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts.

The Rho GTPases in Cancer

Автор: Kenneth van Golen
Название: The Rho GTPases in Cancer
ISBN: 1489982868 ISBN-13(EAN): 9781489982865
Издательство: Springer
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Цена: 26120.00 р.
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Описание: The critical role of Rho GTPases, their regulatory proteins, and their involvement in cancer progression have become increasingly evident in recent years. This is the first volume to collect and summarize the current understanding of Rho GTPases.

Rho Family GTPases

Автор: Edward J. Manser
Название: Rho Family GTPases
ISBN: 9048168732 ISBN-13(EAN): 9789048168736
Издательство: Springer
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Цена: 32004.00 р.
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Описание:

This volume provides a unique collection of detailed chapters from some of the leading research groups in the world, many of which have made key discoveries in the field. This allows for particularly insightful discussion of the current understanding of Rho function.

Work on signal transduction pathways involving Rho family GTPases started some ten years ago. There is now a realization that these highly conserved molecular switches not only serve to coordinate cytoskeletal organization but also impact on diverse aspects of cell biology such as membrane trafficking, transcriptional regulation and mitotic progression.

Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted.

The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases.

The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.

Bacterial Virulence Factors and Rho GTPases

Автор: Patrice Boquet; E. Lemichez
Название: Bacterial Virulence Factors and Rho GTPases
ISBN: 3642062806 ISBN-13(EAN): 9783642062803
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The authors in this volume show a synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfil their virulence.

Introduction to Particle Technology 2 ed.

Автор: Rhodes, Martin
Название: Introduction to Particle Technology 2 ed.
ISBN: 0470014288 ISBN-13(EAN): 9780470014288
Издательство: Wiley
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Цена: 8229.00 р.
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Описание: This textbook is a comprehensive introduction to the many concepts of this broad subject. Case studies are provided alongside real-life industrial applications illustrating the techniques and theory. This book will be essential reading for students of chemical engineering on particle technology courses.

GTPases in Biology II

Автор: M. Biel; Lutz Birnbaumer; K.J. Blumer; J. Bockaert
Название: GTPases in Biology II
ISBN: 3642783473 ISBN-13(EAN): 9783642783470
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life it- self, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring ac- curacy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become t h e reference work for GTPases.

RAS Family GTPases

Автор: Channing Der
Название: RAS Family GTPases
ISBN: 9048171105 ISBN-13(EAN): 9789048171101
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology.


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