Coordinating Organismal Physiology Through the Unfolded Protein Response, Wiseman
Автор: Eleftherios Karanasios; Nicholas T. Ktistakis Название: Autophagy at the Cell, Tissue and Organismal Level ISBN: 3319331434 ISBN-13(EAN): 9783319331430 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: After a historical review ranging up to the identification of autophagy genes in mammals, the authors discuss the signaling pathways that regulate autophagy, the mechanism of autophagosome formation and the physiological roles of autophagy in development, ageing, neurodegeneration, immune function and cell differentiation.
This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.
Автор: Rui Diogo Название: Evolution Driven by Organismal Behavior ISBN: 3319475800 ISBN-13(EAN): 9783319475806 Издательство: Springer Рейтинг: Цена: 5309.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book has an appeal to researchers, students, teachers, and those with an interest in the history and philosophy of science, as well as to the broader public, as it brings life back into biology by emphasizing that organisms, including humans, are the key active players in evolution and thus in the future of life on this wonderful planet.
Автор: Robert Clarke Название: The Unfolded Protein Response in Cancer ISBN: 3030050653 ISBN-13(EAN): 9783030050658 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
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