Coordinating Organismal Physiology Through the Unfolded Protein Response, R. Luke Wiseman; Cole M. Haynes

Автор: Eleftherios Karanasios; Nicholas T. Ktistakis
Название: Autophagy at the Cell, Tissue and Organismal Level
ISBN: 3319331434 ISBN-13(EAN): 9783319331430
Издательство: Springer
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Цена: 9141.00 р.
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Описание: After a historical review ranging up to the identification of autophagy genes in mammals, the authors discuss the signaling pathways that regulate autophagy, the mechanism of autophagosome formation and the physiological roles of autophagy in development, ageing, neurodegeneration, immune function and cell differentiation.

Автор: Rui Diogo
Название: Evolution Driven by Organismal Behavior
ISBN: 3319475800 ISBN-13(EAN): 9783319475806
Издательство: Springer
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Цена: 5309.00 р.
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Описание: The book has an appeal to researchers, students, teachers, and those with an interest in the history and philosophy of science, as well as to the broader public, as it brings life back into biology by emphasizing that organisms, including humans, are the key active players in evolution and thus in the future of life on this wonderful planet.

Автор: Wiseman
Название: Coordinating Organismal Physiology Through the Unfolded Protein Response
ISBN: 331978529X ISBN-13(EAN): 9783319785295
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease.

Автор: Robert Clarke
Название: The Unfolded Protein Response in Cancer
ISBN: 3030050653 ISBN-13(EAN): 9783030050658
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.