Third Generation EGFR Inhibitors, Patel, Harun

Автор: Sir John R. Vane; Jack H. Botting
Название: Selective COX-2 Inhibitors
ISBN: 940106041X ISBN-13(EAN): 9789401060417
Издательство: Springer
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Цена: 13974.00 р.
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Описание: ` The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result- ing from inhibition of the constitutive enzyme.

Автор: G. Strube
Название: ACE Inhibitors in Hypertension
ISBN: 9401057370 ISBN-13(EAN): 9789401057370
Издательство: Springer
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Цена: 6986.00 р.
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Описание: The treatment of hypertension has progressed in stages following the development of a succession of increasingly effective drugs, each allowing a greater proportion of patients to be treated with fewer and fewer side-effects.

Автор: Gerry A. Higgs; Brian Henderson
Название: Novel Cytokine Inhibitors
ISBN: 3034895720 ISBN-13(EAN): 9783034895729
Издательство: Springer
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Цена: 6986.00 р.
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Описание: It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors.

Автор: Nicola J. Curtin; Ricky A. Sharma
Название: PARP Inhibitors for Cancer Therapy
ISBN: 3319141503 ISBN-13(EAN): 9783319141503
Издательство: Springer
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Цена: 23757.00 р.
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.

Автор: Sir John R. Vane; Jack H. Botting; R.M. Botting
Название: Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors
ISBN: 9401090319 ISBN-13(EAN): 9789401090315
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.

Автор: Giancarlo Folco; Bengt Samuelsson; Robert C. Murph
Название: Novel Inhibitors of Leukotrienes
ISBN: 3034897367 ISBN-13(EAN): 9783034897365
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s.

Автор: Claudiu T. Supuran; Clemente Capasso
Название: Zinc Enzyme Inhibitors
ISBN: 3319461117 ISBN-13(EAN): 9783319461113
Издательство: Springer
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Цена: 30745.00 р.
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Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Автор: Robert B. Sim
Название: Activators and Inhibitors of Complement
ISBN: 9401052247 ISBN-13(EAN): 9789401052245
Издательство: Springer
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Цена: 28734.00 р.
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Автор: Timothy D. Warner
Название: Endothelin and Its Inhibitors
ISBN: 3642632378 ISBN-13(EAN): 9783642632372
Издательство: Springer
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Цена: 6986.00 р.
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Описание: With contributions by numerous experts

Автор: Ingo K. Mellinghoff; Charles L. Sawyers
Название: Therapeutic Kinase Inhibitors
ISBN: 3642445802 ISBN-13(EAN): 9783642445804
Издательство: Springer
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Цена: 26120.00 р.
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Описание:

Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as chemotherapy and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates.

This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editorsinvited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authorshope these lessons will be instructive for the novice as well as the expert. "