Описание: Peritoneal dissemination is a common route of cancer metastasis. The benefit of administering chemotherapy directly into the peritoneal cavity is supported by preclinical and pharmacokinetic data. In comparison to intravenous (IV) treatment, intraperitoneal (IP) administration results in a several-fold increase in drug concentration within the abdominal cavity. There is now growing evidence from clinical studies showing a survival advantage for IP chemotherapy in various tumor typies, including ovarian, gastric and colorectal cancer.However, while the use of IP chemotherapy is slowly gaining acceptance, it is not universal, largely due to the greater toxicity associated with this approach. Moreover, efficacy of IP chemotherapy is limited by poor distribution within the abdominal cavity and by poor tissue penetration. A new way of IP chemotherapy is the application of cytotoxics in form of a pressurized aerosol into the abdominal of thoracic cavity. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied through laparoscopic access using two balloon trocars in an operating room equipped with laminar air-flow. In a first step,a normothermic capnoperitoneum is established with a pressure of 12 mmHg. A cytotoxic solution (about 10% of a normal systemic dose) is nebulized with a micropump into the abdominal cavity, and maintained for 30 min. The aerosol is then removed through a closed suction system. Applying an aerosol in the peritoneal cavity allows a homogeneous distribution of the chemotherapeutic agent within the abdomen. Furthermore, an artificial pressure gradient is generated that overcomes tumoral interstitial fluid pressure, an obstacle in cancer therapy. This results in a higher local drug concentration compared to conventional IP or IV chemotherapy. At the same time the plasma concentration of the chemotherapeutic agent remains low. In first clinical studies with limited number of patients in ovarian, gastric and colorectal cancer, as well as peritoneal mesothelioma, PIPAC has obtained encouraging tumor response rates and survival, with a low-side effects profile. Larger clinical trials are currently ongoing to examine if these data can be reproduced and extrapolated to other situations.
Автор: Sergei Mariev, Wiebke-Marie Stock Название: Aesthetics and Theurgy in Byzantium ISBN: 1614513279 ISBN-13(EAN): 9781614513278 Издательство: Walter de Gruyter Цена: 20446.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The general scope of the present volume is to present a variety of approaches and topics within the growing field of research on Byzantine aesthetics. Theurgy in Neoplatonic and Christian contexts is represented by the contributions of W.-M. Stock and L. Bergemann; theories of beauty are at the centre of interest of the papers by S. Mariev and M. Marchetto. A. Pizzone approaches Byzantine aesthetics by looking for aesthetic experience in the literary texts, while the remaining contributions explore issues related to the iconoclast controversy: An important moment in the development of Byzantine philosophy on the eve of iconoclasm is the primary interest of A. del Campo Echevarria, who looks at the question of universals in John of Damaskos. The relationship between image and text in Byzantine illustrated manuscripts occupies the attention of B. Crostini. D. Afinogenov explores from a philological perspective the fate of important iconophile terminology in Old Bulgarian, while L. Lukhovitskij reconstructs from historical and philological perspectives the historical memory of the iconoclast controversy during the Late Byzantine Period.
Автор: Denecke Wiebke Название: Oxford Handbook of Classical Chinese Literature ISBN: 0199356599 ISBN-13(EAN): 9780199356591 Издательство: Oxford Academ Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume introduces readers to classical Chinese literature from its beginnings (ca. 10th century BCE) to the tenth century BCE through a conceptual framework centered on textual production and transmission. It focuses on recuperating historical perspectives for the period it surveys, and attempts to draw connections between the past and present.
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