Cancer: Blueprint of a Tumor, Michael Dean, Karobi Moitra

Автор: Pecorino Lauren
Название: Molecular Biology of Cancer
ISBN: 0198717342 ISBN-13(EAN): 9780198717348
Издательство: Oxford Academ
Рейтинг:
Цена: 7126.00 р.
Наличие на складе: Поставка под заказ.

Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers the most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear.

Автор: Gerard P. Zambetti
Название: The p53 Tumor Suppressor Pathway and Cancer
ISBN: 1489998799 ISBN-13(EAN): 9781489998798
Издательство: Springer
Рейтинг:
Цена: 26120.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells.

Автор: Michael Dean, Karobi Moitra
Название: Cancer: Blueprint of a Tumor
ISBN: 1615047948 ISBN-13(EAN): 9781615047949
Издательство: Mare Nostrum (Eurospan)
Рейтинг:
Цена: 5010.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.

Автор: Daniel Roses
Название: Breast Cancer
ISBN: 0443066345 ISBN-13(EAN): 9780443066344
Издательство: Amazon Internet
Рейтинг:
Цена: 21780.00 р.
Наличие на складе: Невозможна поставка.

Описание: Provides understanding of breast cancer from biology, pathology, and screening through diagnosis, treatment, long-term follow-up, and adjuvant care. This volume addresses the concerns of a member of the health care team. A question-and-answer format offers answers to clinical questions.