Cancer: Blueprint of a Tumor, Michael Dean, Karobi Moitra
Автор: Pecorino Lauren Название: Molecular Biology of Cancer ISBN: 0198717342 ISBN-13(EAN): 9780198717348 Издательство: Oxford Academ Рейтинг: Цена: 7126.00 р. Наличие на складе: Поставка под заказ.
Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers the most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear.
Автор: Gerald Litwack Название: Hormones and Breast Cancer, ISBN: 0124166733 ISBN-13(EAN): 9780124166738 Издательство: Elsevier Science Рейтинг: Цена: 15091.00 р. 21559.00-30% Наличие на складе: Есть (1 шт.) Описание: Reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. This volume focuses on hormones and breast cancer.
Автор: Goldie Название: Drug Resistance in Cancer ISBN: 0521482739 ISBN-13(EAN): 9780521482738 Издательство: Cambridge Academ Рейтинг: Цена: 23443.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an accessible yet sophisticated account of the mechanisms responsible for drug resistance in cancer. In addition, the authors use clearly explained mathematical models to provide an insight into tumour development and the effectiveness and limitations of drug treatment.
Автор: Michael Dean, Karobi Moitra Название: Cancer: Blueprint of a Tumor ISBN: 1615047964 ISBN-13(EAN): 9781615047963 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 7518.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.
Автор: Gerard P. Zambetti Название: The p53 Tumor Suppressor Pathway and Cancer ISBN: 1489998799 ISBN-13(EAN): 9781489998798 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells.
Автор: Paul B Fisher and Carlo Croce Название: Advances in Cancer Research: Volume 135. Mirna and cancer ISBN: 0128119225 ISBN-13(EAN): 9780128119228 Издательство: Elsevier Science Рейтинг: Цена: 20043.00 р. Наличие на складе: Поставка под заказ.
Описание:
miRNA and Cancer, Volume 135, the latest volume in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, and includes specific chapters on Non-coding RNAs as Biomarkers of Cancer, The Enigma of microRNA Regulation in Cancer, Animal Models to Study microRNA functions, Non-coding RNAs and Cancer, microRNAs in Cancer Susceptibility, ts-RNAs versus microRNAs, microRNAs and AML, and microRNAs and Epigenetics.
Автор: Daniel Roses Название: Breast Cancer ISBN: 0443066345 ISBN-13(EAN): 9780443066344 Издательство: Amazon Internet Рейтинг: Цена: 21780.00 р. Наличие на складе: Невозможна поставка.
Описание: Provides understanding of breast cancer from biology, pathology, and screening through diagnosis, treatment, long-term follow-up, and adjuvant care. This volume addresses the concerns of a member of the health care team. A question-and-answer format offers answers to clinical questions.
Автор: Kelley, Mark R. Название: DNA Repair in Cancer Therapy ISBN: 012803582X ISBN-13(EAN): 9780128035825 Издательство: Elsevier Science Рейтинг: Цена: 18696.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.
Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs.
Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors.
Описание: Includes interviews with 2018 Nobel Prize Winners James Allison and Tasuku Honjo The way we treat cancer is about to change forever. This revolution--and it is precisely that--was sparked not by the invention of a new drug, but by the evolution of an entirely new way of thinking about and managing cancer. Going forward, doctors will not use pharmaceuticals to attack tumors--not directly. Rather, the oncologist will treat the patient's immune system with a drug, and then the patient will treat the tumor. Based entirely on interviews with the investigators, this book is the story of the immuno-oncology pioneers. It's a story of failure, resurrection, and success. It's a story about science, it's a story about discovery, and intuition, and cunning. It's a peek into the lives and thoughts of some of the most gifted medical scientists on the planet. This is not a textbook. This is a life book. This technology will save/is saving lives, and the book celebrates the living, breathing, thinking, charming, arrogant, funny, obstinate, amazing human beings who are making immuno-oncology happen. The stories and lives shared in this book show readers the decades of devotion and passion it takes to imagine a better world and then make it happen. If this book motivates even one more similarly talented and visionary investigator to deliver on their promise it would be a wonderful success. -- Clifford A. Hudis, MD, FACP, FASCO Chief Executive Officer, American Society of Clinical Oncology
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